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Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells**
THE FIRST CELL-PENETRATING PEPTIDE: that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531619/ https://www.ncbi.nlm.nih.gov/pubmed/22962028 http://dx.doi.org/10.1002/anie.201204308 |