Cargando…

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a complex sequence of tightly regulated events. The assembly of specialized SNARE complexes plays a pivotal role in this process. The function of the chaperone cysteine string protein α (CSPα) is importan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ninkina, Natalia, Peters, Owen M., Connor-Robson, Natalie, Lytkina, Olga, Sharfeddin, Essam, Buchman, Vladimir L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531760/ https://www.ncbi.nlm.nih.gov/pubmed/23129765 http://dx.doi.org/10.1074/jbc.M112.422402

Ejemplares similares

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
por: Herva, Maria Eugenia, et al.
Publicado: (2014)

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo
por: Lou, Haiyan, et al.
Publicado: (2010)

α-Synuclein facilitates endocytosis by elevating the steady-state levels of phosphatidylinositol 4,5-bisphosphate
por: Schechter, Meir, et al.
Publicado: (2021)

α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
por: Morgan, Sophie A., et al.
Publicado: (2020)

Intracellular soluble α‐synuclein oligomers reduce pyramidal cell excitability
por: Kaufmann, Timothy J., et al.
Publicado: (2016)

Quercetin Targets Cysteine String Protein (CSPα) and Impairs Synaptic Transmission
por: Xu, Fenglian, et al.
Publicado: (2010)

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
por: Buchman, Vladimir L., et al.
Publicado: (2008)

Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson’s disease
por: Nam, Daleum, et al.
Publicado: (2021)

Ca(2+)/Calmodulin-dependent Protein Kinase IIα (αCaMKII) Controls the Activity of the Dopamine Transporter: IMPLICATIONS FOR ANGELMAN SYNDROME
por: Steinkellner, Thomas, et al.
Publicado: (2012)

The Association between α-Synuclein and α-Tubulin in Brain Synapses
por: Amadeo, Alida, et al.
Publicado: (2021)

CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
por: Caló, Laura, et al.
Publicado: (2021)

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
por: Delbart, Florian, et al.
Publicado: (2018)

Dopamine and α-synuclein dysfunction in Smad3 null mice
por: Tapia-González, Silvia, et al.
Publicado: (2011)

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice()
por: Al-Wandi, Abdelmojib, et al.
Publicado: (2010)

Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain
por: Reissner, Carsten, et al.
Publicado: (2014)

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression
por: Ninkina, Natalia, et al.
Publicado: (2015)

Choline Promotes Nicotinic Receptor α4 + β2 Up-regulation
por: Gahring, Lorise C., et al.
Publicado: (2010)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Calcium Currents Are Enhanced by α(2)δ-1 Lacking Its Membrane Anchor
por: Kadurin, Ivan, et al.
Publicado: (2012)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

α-Synuclein liquid condensates fuel fibrillar α-synuclein growth
por: Piroska, Leonard, et al.
Publicado: (2023)

Lipid Classes and Fatty Acid Patterns are Altered in the Brain of γ-Synuclein Null Mutant Mice
por: Guschina, Irina, et al.
Publicado: (2010)

Proteomic Analysis of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Complexes
por: Kang, Myoung-Goo, et al.
Publicado: (2012)

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
por: Gill-Thind, JasKiran K., et al.
Publicado: (2015)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses
por: Verpelli, Chiara, et al.
Publicado: (2011)

Detrimental effects of soluble α-synuclein oligomers at excitatory glutamatergic synapses
por: Ferrari, Elena, et al.
Publicado: (2023)

Small GTPase Rab17 Regulates the Surface Expression of Kainate Receptors but Not α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors in Hippocampal Neurons via Dendritic Trafficking of Syntaxin-4 Protein
por: Mori, Yasunori, et al.
Publicado: (2014)

An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3
por: Fukui, Naoya, et al.
Publicado: (2021)

Presynaptically Silent Synapses Studied with Light Microscopy
por: Moulder, Krista L., et al.
Publicado: (2010)

Cysteine string protein (CSP) and its role in preventing neurodegeneration
por: Burgoyne, Robert D., et al.
Publicado: (2015)

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
por: Sacino, Amanda N, et al.
Publicado: (2013)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Inducing α-synuclein compaction: a new strategy for inhibiting α-synuclein aggregation?
por: Pinheiro, Francisca, et al.
Publicado: (2019)

CSPα—chaperoning presynaptic proteins
por: Donnelier, Julien, et al.
Publicado: (2014)

Alterations in the nigrostriatal system following conditional inactivation of α-synuclein in neurons of adult and aging mice
por: Ninkina, Natalia, et al.
Publicado: (2020)

Copper(II) Binding to α-Synuclein, the Parkinson’s Protein
por: Lee, Jennifer C., et al.
Publicado: (2008)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Modulating the Amyloidogenesis of α-Synuclein
por: Sivanesam, Kalkena, et al.
Publicado: (2016)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cmvt9b0jb6kmbn1ii72uc949oe