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Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer

Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liv...

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Autores principales: Honda, Takayuki, Kobayashi, Hiroaki, Saiki, Masafumi, Sogami, Yusuke, Miyashita, Yoshihiro, Inase, Naohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531950/
https://www.ncbi.nlm.nih.gov/pubmed/23275780
http://dx.doi.org/10.1159/000345956
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author Honda, Takayuki
Kobayashi, Hiroaki
Saiki, Masafumi
Sogami, Yusuke
Miyashita, Yoshihiro
Inase, Naohiko
author_facet Honda, Takayuki
Kobayashi, Hiroaki
Saiki, Masafumi
Sogami, Yusuke
Miyashita, Yoshihiro
Inase, Naohiko
author_sort Honda, Takayuki
collection PubMed
description Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liver is a frequent site of cancer metastasis, but diffuse hepatic sinusoidal metastasis is uncommon as a metastatic form of NSCLC. This report describes a patient with gastroesophageal variceal hemorrhage owing to a metastatic liver tumor of NSCLC. The patient, a male smoker with stage IV NSCLC, was free of any hepatitis viral infection and had no alcohol addiction. Liver dysfunction and liver disease had never been pointed out in his medical history. His tumor harbored an L858R epidermal growth factor receptor mutation. Gefitinib was initiated but had to be ceased because of interstitial lung disease. Sequential steroid therapy was effective and bevacizumab-containing chemotherapy was commenced. Both chemotherapy regimens produced favorable effects against the metastatic liver tumor, eliciting atrophic change regardless of the chemotherapy-free interval. One day the patient was admitted to our hospital because of black stool and hypotension. Upper gastrointestinal endoscopy revealed a beaded appearance of the gastroesophageal varix with bloody gastric contents. The portal hypertension might have been caused by changes in portal vein hemodynamics induced by the conformational changes underlying the favorable response of the liver tumor to molecular targeted chemotherapy and notable regression.
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spelling pubmed-35319502012-12-28 Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer Honda, Takayuki Kobayashi, Hiroaki Saiki, Masafumi Sogami, Yusuke Miyashita, Yoshihiro Inase, Naohiko Case Rep Oncol Published online: December, 2012 Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liver is a frequent site of cancer metastasis, but diffuse hepatic sinusoidal metastasis is uncommon as a metastatic form of NSCLC. This report describes a patient with gastroesophageal variceal hemorrhage owing to a metastatic liver tumor of NSCLC. The patient, a male smoker with stage IV NSCLC, was free of any hepatitis viral infection and had no alcohol addiction. Liver dysfunction and liver disease had never been pointed out in his medical history. His tumor harbored an L858R epidermal growth factor receptor mutation. Gefitinib was initiated but had to be ceased because of interstitial lung disease. Sequential steroid therapy was effective and bevacizumab-containing chemotherapy was commenced. Both chemotherapy regimens produced favorable effects against the metastatic liver tumor, eliciting atrophic change regardless of the chemotherapy-free interval. One day the patient was admitted to our hospital because of black stool and hypotension. Upper gastrointestinal endoscopy revealed a beaded appearance of the gastroesophageal varix with bloody gastric contents. The portal hypertension might have been caused by changes in portal vein hemodynamics induced by the conformational changes underlying the favorable response of the liver tumor to molecular targeted chemotherapy and notable regression. S. Karger AG 2012-12-06 /pmc/articles/PMC3531950/ /pubmed/23275780 http://dx.doi.org/10.1159/000345956 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: December, 2012
Honda, Takayuki
Kobayashi, Hiroaki
Saiki, Masafumi
Sogami, Yusuke
Miyashita, Yoshihiro
Inase, Naohiko
Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title_full Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title_fullStr Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title_full_unstemmed Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title_short Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
title_sort gastroesphageal variceal hemorrhage induced by metastatic liver tumor of lung cancer
topic Published online: December, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531950/
https://www.ncbi.nlm.nih.gov/pubmed/23275780
http://dx.doi.org/10.1159/000345956
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