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Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer
Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liv...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531950/ https://www.ncbi.nlm.nih.gov/pubmed/23275780 http://dx.doi.org/10.1159/000345956 |
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author | Honda, Takayuki Kobayashi, Hiroaki Saiki, Masafumi Sogami, Yusuke Miyashita, Yoshihiro Inase, Naohiko |
author_facet | Honda, Takayuki Kobayashi, Hiroaki Saiki, Masafumi Sogami, Yusuke Miyashita, Yoshihiro Inase, Naohiko |
author_sort | Honda, Takayuki |
collection | PubMed |
description | Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liver is a frequent site of cancer metastasis, but diffuse hepatic sinusoidal metastasis is uncommon as a metastatic form of NSCLC. This report describes a patient with gastroesophageal variceal hemorrhage owing to a metastatic liver tumor of NSCLC. The patient, a male smoker with stage IV NSCLC, was free of any hepatitis viral infection and had no alcohol addiction. Liver dysfunction and liver disease had never been pointed out in his medical history. His tumor harbored an L858R epidermal growth factor receptor mutation. Gefitinib was initiated but had to be ceased because of interstitial lung disease. Sequential steroid therapy was effective and bevacizumab-containing chemotherapy was commenced. Both chemotherapy regimens produced favorable effects against the metastatic liver tumor, eliciting atrophic change regardless of the chemotherapy-free interval. One day the patient was admitted to our hospital because of black stool and hypotension. Upper gastrointestinal endoscopy revealed a beaded appearance of the gastroesophageal varix with bloody gastric contents. The portal hypertension might have been caused by changes in portal vein hemodynamics induced by the conformational changes underlying the favorable response of the liver tumor to molecular targeted chemotherapy and notable regression. |
format | Online Article Text |
id | pubmed-3531950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-35319502012-12-28 Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer Honda, Takayuki Kobayashi, Hiroaki Saiki, Masafumi Sogami, Yusuke Miyashita, Yoshihiro Inase, Naohiko Case Rep Oncol Published online: December, 2012 Gastroesophageal variceal hemorrhage is a lethal complication of portal hypertension. Liver cirrhosis is often the principal cause of the portal hypertensive state. Malignant tumors coexist with portal hypertension in some cases. Non-small-cell lung cancer (NSCLC) is likely to become metastatic. Liver is a frequent site of cancer metastasis, but diffuse hepatic sinusoidal metastasis is uncommon as a metastatic form of NSCLC. This report describes a patient with gastroesophageal variceal hemorrhage owing to a metastatic liver tumor of NSCLC. The patient, a male smoker with stage IV NSCLC, was free of any hepatitis viral infection and had no alcohol addiction. Liver dysfunction and liver disease had never been pointed out in his medical history. His tumor harbored an L858R epidermal growth factor receptor mutation. Gefitinib was initiated but had to be ceased because of interstitial lung disease. Sequential steroid therapy was effective and bevacizumab-containing chemotherapy was commenced. Both chemotherapy regimens produced favorable effects against the metastatic liver tumor, eliciting atrophic change regardless of the chemotherapy-free interval. One day the patient was admitted to our hospital because of black stool and hypotension. Upper gastrointestinal endoscopy revealed a beaded appearance of the gastroesophageal varix with bloody gastric contents. The portal hypertension might have been caused by changes in portal vein hemodynamics induced by the conformational changes underlying the favorable response of the liver tumor to molecular targeted chemotherapy and notable regression. S. Karger AG 2012-12-06 /pmc/articles/PMC3531950/ /pubmed/23275780 http://dx.doi.org/10.1159/000345956 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: December, 2012 Honda, Takayuki Kobayashi, Hiroaki Saiki, Masafumi Sogami, Yusuke Miyashita, Yoshihiro Inase, Naohiko Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title | Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title_full | Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title_fullStr | Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title_full_unstemmed | Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title_short | Gastroesphageal Variceal Hemorrhage Induced by Metastatic Liver Tumor of Lung Cancer |
title_sort | gastroesphageal variceal hemorrhage induced by metastatic liver tumor of lung cancer |
topic | Published online: December, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531950/ https://www.ncbi.nlm.nih.gov/pubmed/23275780 http://dx.doi.org/10.1159/000345956 |
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