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Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report

Micropapillary carcinoma was originally reported to be an aggressive variant of breast carcinoma, and it is associated with frequent lymphovascular invasion and a dismal clinical outcome. It has subsequently been found in other organs; however, at present, only a limited number of cases of colorecta...

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Autores principales: Mukai, Shoichiro, Takakura, Yuji, Egi, Hiroyuki, Hinoi, Takao, Saito, Yasufumi, Tanimine, Naoki, Miguchi, Masashi, Adachi, Tomohiro, Shimomura, Manabu, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531951/
https://www.ncbi.nlm.nih.gov/pubmed/23275774
http://dx.doi.org/10.1159/000345566
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author Mukai, Shoichiro
Takakura, Yuji
Egi, Hiroyuki
Hinoi, Takao
Saito, Yasufumi
Tanimine, Naoki
Miguchi, Masashi
Adachi, Tomohiro
Shimomura, Manabu
Ohdan, Hideki
author_facet Mukai, Shoichiro
Takakura, Yuji
Egi, Hiroyuki
Hinoi, Takao
Saito, Yasufumi
Tanimine, Naoki
Miguchi, Masashi
Adachi, Tomohiro
Shimomura, Manabu
Ohdan, Hideki
author_sort Mukai, Shoichiro
collection PubMed
description Micropapillary carcinoma was originally reported to be an aggressive variant of breast carcinoma, and it is associated with frequent lymphovascular invasion and a dismal clinical outcome. It has subsequently been found in other organs; however, at present, only a limited number of cases of colorectal micropapillary carcinoma have been reported. We present a case of early colon cancer with extensive nodal metastases in a Japanese patient. An 82-year-old man was found by colonoscopy to have a 20-mm pedunculated polyp in his sigmoid colon. Endoscopic resection of the sigmoid colon tumor was performed, and pathological examination of the resected specimen revealed a poorly differentiated adenocarcinoma component and a micropapillary component. Despite the tumor being confined within the submucosa, massive lymphatic invasion was noted. Thereafter, the patient underwent laparoscopic sigmoidectomy with lymph node dissection, and multiple lymph node metastases were observed. Our case suggests that when a micropapillary component is identified in a pre-operative biopsy specimen, even for early colorectal cancer, surgical resection with adequate lymph node dissection would be required because of the high potential for nodal metastases.
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spelling pubmed-35319512012-12-28 Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report Mukai, Shoichiro Takakura, Yuji Egi, Hiroyuki Hinoi, Takao Saito, Yasufumi Tanimine, Naoki Miguchi, Masashi Adachi, Tomohiro Shimomura, Manabu Ohdan, Hideki Case Rep Oncol Published online: November, 2012 Micropapillary carcinoma was originally reported to be an aggressive variant of breast carcinoma, and it is associated with frequent lymphovascular invasion and a dismal clinical outcome. It has subsequently been found in other organs; however, at present, only a limited number of cases of colorectal micropapillary carcinoma have been reported. We present a case of early colon cancer with extensive nodal metastases in a Japanese patient. An 82-year-old man was found by colonoscopy to have a 20-mm pedunculated polyp in his sigmoid colon. Endoscopic resection of the sigmoid colon tumor was performed, and pathological examination of the resected specimen revealed a poorly differentiated adenocarcinoma component and a micropapillary component. Despite the tumor being confined within the submucosa, massive lymphatic invasion was noted. Thereafter, the patient underwent laparoscopic sigmoidectomy with lymph node dissection, and multiple lymph node metastases were observed. Our case suggests that when a micropapillary component is identified in a pre-operative biopsy specimen, even for early colorectal cancer, surgical resection with adequate lymph node dissection would be required because of the high potential for nodal metastases. S. Karger AG 2012-09-20 /pmc/articles/PMC3531951/ /pubmed/23275774 http://dx.doi.org/10.1159/000345566 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: November, 2012
Mukai, Shoichiro
Takakura, Yuji
Egi, Hiroyuki
Hinoi, Takao
Saito, Yasufumi
Tanimine, Naoki
Miguchi, Masashi
Adachi, Tomohiro
Shimomura, Manabu
Ohdan, Hideki
Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title_full Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title_fullStr Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title_full_unstemmed Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title_short Submucosal Invasive Micropapillary Carcinoma of the Colon with Massive Lymph Node Metastases: A Case Report
title_sort submucosal invasive micropapillary carcinoma of the colon with massive lymph node metastases: a case report
topic Published online: November, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531951/
https://www.ncbi.nlm.nih.gov/pubmed/23275774
http://dx.doi.org/10.1159/000345566
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