Cargando…

RON is not a prognostic marker for resectable pancreatic cancer

BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer i...

Descripción completa

Detalles Bibliográficos
Autores principales: Tactacan, Carole M, Chang, David K, Cowley, Mark J, Humphrey, Emily S, Wu, Jianmin, Gill, Anthony J, Chou, Angela, Nones, Katia, Grimmond, Sean M, Sutherland, Robert L, Biankin, Andrew V, Daly, Roger J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532183/
https://www.ncbi.nlm.nih.gov/pubmed/22958871
http://dx.doi.org/10.1186/1471-2407-12-395
_version_ 1782254267413823488
author Tactacan, Carole M
Chang, David K
Cowley, Mark J
Humphrey, Emily S
Wu, Jianmin
Gill, Anthony J
Chou, Angela
Nones, Katia
Grimmond, Sean M
Sutherland, Robert L
Biankin, Andrew V
Daly, Roger J
author_facet Tactacan, Carole M
Chang, David K
Cowley, Mark J
Humphrey, Emily S
Wu, Jianmin
Gill, Anthony J
Chou, Angela
Nones, Katia
Grimmond, Sean M
Sutherland, Robert L
Biankin, Andrew V
Daly, Roger J
author_sort Tactacan, Carole M
collection PubMed
description BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer.
format Online
Article
Text
id pubmed-3532183
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35321832013-01-03 RON is not a prognostic marker for resectable pancreatic cancer Tactacan, Carole M Chang, David K Cowley, Mark J Humphrey, Emily S Wu, Jianmin Gill, Anthony J Chou, Angela Nones, Katia Grimmond, Sean M Sutherland, Robert L Biankin, Andrew V Daly, Roger J BMC Cancer Research Article BACKGROUND: The receptor tyrosine kinase RON exhibits increased expression during pancreatic cancer progression and promotes migration, invasion and gemcitabine resistance of pancreatic cancer cells in experimental models. However, the prognostic significance of RON expression in pancreatic cancer is unknown. METHODS: RON expression was characterized in several large cohorts, including a prospective study, totaling 492 pancreatic cancer patients and relationships with patient outcome and clinico-pathologic variables were assessed. RESULTS: RON expression was associated with outcome in a training set, but this was not recapitulated in the validation set, nor was there any association with therapeutic responsiveness in the validation set or the prospective study. CONCLUSIONS: Although RON is implicated in pancreatic cancer progression in experimental models, and may constitute a therapeutic target, RON expression is not associated with prognosis or therapeutic responsiveness in resected pancreatic cancer. BioMed Central 2012-09-07 /pmc/articles/PMC3532183/ /pubmed/22958871 http://dx.doi.org/10.1186/1471-2407-12-395 Text en Copyright ©2012 Tactacan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tactacan, Carole M
Chang, David K
Cowley, Mark J
Humphrey, Emily S
Wu, Jianmin
Gill, Anthony J
Chou, Angela
Nones, Katia
Grimmond, Sean M
Sutherland, Robert L
Biankin, Andrew V
Daly, Roger J
RON is not a prognostic marker for resectable pancreatic cancer
title RON is not a prognostic marker for resectable pancreatic cancer
title_full RON is not a prognostic marker for resectable pancreatic cancer
title_fullStr RON is not a prognostic marker for resectable pancreatic cancer
title_full_unstemmed RON is not a prognostic marker for resectable pancreatic cancer
title_short RON is not a prognostic marker for resectable pancreatic cancer
title_sort ron is not a prognostic marker for resectable pancreatic cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532183/
https://www.ncbi.nlm.nih.gov/pubmed/22958871
http://dx.doi.org/10.1186/1471-2407-12-395
work_keys_str_mv AT tactacancarolem ronisnotaprognosticmarkerforresectablepancreaticcancer
AT changdavidk ronisnotaprognosticmarkerforresectablepancreaticcancer
AT cowleymarkj ronisnotaprognosticmarkerforresectablepancreaticcancer
AT humphreyemilys ronisnotaprognosticmarkerforresectablepancreaticcancer
AT wujianmin ronisnotaprognosticmarkerforresectablepancreaticcancer
AT gillanthonyj ronisnotaprognosticmarkerforresectablepancreaticcancer
AT chouangela ronisnotaprognosticmarkerforresectablepancreaticcancer
AT noneskatia ronisnotaprognosticmarkerforresectablepancreaticcancer
AT grimmondseanm ronisnotaprognosticmarkerforresectablepancreaticcancer
AT sutherlandrobertl ronisnotaprognosticmarkerforresectablepancreaticcancer
AT biankinandrewv ronisnotaprognosticmarkerforresectablepancreaticcancer
AT dalyrogerj ronisnotaprognosticmarkerforresectablepancreaticcancer