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A combination of intradermal jet-injection and electroporation overcomes in vivo dose restriction of DNA vaccines

BACKGROUND: The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacious in humans. METHODS: Herein we evaluated antigen expression and immunogenicit...

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Detalles Bibliográficos
Autores principales:	Hallengärd, David, Bråve, Andreas, Isaguliants, Maria, Blomberg, Pontus, Enger, Jenny, Stout, Richard, King, Alan, Wahren, Britta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532290/ https://www.ncbi.nlm.nih.gov/pubmed/22873174 http://dx.doi.org/10.1186/1479-0556-10-5

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