Positive Selection in the Chromosome 16 VKORC1 Genomic Region Has Contributed to the Variability of Anticoagulant Response in Humans

VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK). This gene was recently suggested to be a putative target of positive selection in East Asian populations. In this study, we genotyped...

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Detalles Bibliográficos
Autores principales: Patillon, Blandine, Luisi, Pierre, Blanché, Hélène, Patin, Etienne, Cann, Howard M., Génin, Emmanuelle, Sabbagh, Audrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532425/
https://www.ncbi.nlm.nih.gov/pubmed/23285254
http://dx.doi.org/10.1371/journal.pone.0053049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532425/
https://www.ncbi.nlm.nih.gov/pubmed/23285254
http://dx.doi.org/10.1371/journal.pone.0053049

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