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Determining Duration of HER2-Targeted Therapy Using Stem Cell Extinction Models

INTRODUCTION: Trastuzumab dramatically improves survival in breast cancer patients whose tumor overexpresses HER2. A subpopulation of cells in human breast tumors has been identified with characteristics of cancer stem cells. These breast cancer stem-like cells (BCSCs) rely on HER2 signaling for sel...

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Detalles Bibliográficos
Autores principales:	Riley, Lindsay, Zhou, Hua, Lange, Kenneth, Sinsheimer, Janet S., Sehl, Mary E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532453/ https://www.ncbi.nlm.nih.gov/pubmed/23284608 http://dx.doi.org/10.1371/journal.pone.0046613

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