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Development and Validation of an Immunoassay for Quantification of Topoisomerase I in Solid Tumor Tissues

BACKGROUND: Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a correlation may help identify patients...

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Detalles Bibliográficos
Autores principales:	Pfister, Thomas D., Hollingshead, Melinda, Kinders, Robert J., Zhang, Yiping, Evrard, Yvonne A., Ji, Jiuping, Khin, Sonny A., Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532478/ https://www.ncbi.nlm.nih.gov/pubmed/23284638 http://dx.doi.org/10.1371/journal.pone.0050494

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