Cargando…

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

OBJECTIVE: Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahasan, Mohammad M, Hardy, Rowan, Jones, Christopher, Kaur, Kirren, Nanus, Dominika, Juarez, Maria, Morgan, Stuart A, Hassan-Smith, Zaki, Bénézech, Cécile, Caamaño, Jorge H, Hewison, Martin, Lavery, Gareth, Rabbitt, Elizabeth H, Clark, Andrew R, Filer, Andrew, Buckley, Christopher D, Raza, Karim, Stewart, Paul M, Cooper, Mark S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:	Glucocorticoids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532601/ https://www.ncbi.nlm.nih.gov/pubmed/22294469 http://dx.doi.org/10.1002/art.34414

Ejemplares similares

Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis
por: Nanus, Dominika E, et al.
Publicado: (2015)

Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis
por: Hardy, Rowan, et al.
Publicado: (2012)

Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1
por: Lavery, Gareth G., et al.
Publicado: (2012)

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss
por: Kaur, K, et al.
Publicado: (2009)

Local and systemic glucocorticoid metabolism in inflammatory arthritis
por: Hardy, R, et al.
Publicado: (2008)

An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess
por: Bentley, Liz, et al.
Publicado: (2014)

Acute Glucocorticoid Administration Rapidly Suppresses Basal and Stress-Induced Hypothalamo-Pituitary-Adrenal Axis Activity
por: Andrews, Marcus H., et al.
Publicado: (2012)

Circadian and Ultradian Rhythms of Free Glucocorticoid Hormone Are Highly Synchronized between the Blood, the Subcutaneous Tissue, and the Brain
por: Qian, Xiaoxiao, et al.
Publicado: (2012)

Transgenerational Effects of Prenatal Synthetic Glucocorticoids on Hypothalamic-Pituitary-Adrenal Function
por: Iqbal, Majid, et al.
Publicado: (2012)

Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
por: Hardy, Rowan S, et al.
Publicado: (2006)

Prenatal Synthetic Glucocorticoid Treatment Changes DNA Methylation States in Male Organ Systems: Multigenerational Effects
por: Crudo, Ariann, et al.
Publicado: (2012)

Central Nervous System (CNS) Delivery of Glucocorticoids Is Fine-Tuned by Saturable Transporters at the Blood-CNS Barriers and Nonbarrier Regions
por: Mason, Brittany L., et al.
Publicado: (2010)

Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis
por: Webster, Justine M., et al.
Publicado: (2021)

Deficiency of ALADIN Impairs Redox Homeostasis in Human Adrenal Cells and Inhibits Steroidogenesis
por: Prasad, R., et al.
Publicado: (2013)

OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
por: Webster, Justine, et al.
Publicado: (2019)

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice
por: Coutinho, Agnes E., et al.
Publicado: (2012)

Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells
por: Cooray, Sadani N., et al.
Publicado: (2011)

Adaptive Changes in Basal and Stress-Induced HPA Activity in Lactating and Post-Lactating Female Rats
por: Windle, Richard J., et al.
Publicado: (2013)

SAT-003 Therapeutic Glucocorticoids Prevent Local and Systemic Bone Loss but Exacerbate Muscle Wasting When Administered in Chronic Inflammation
por: Fenton, Chloe, et al.
Publicado: (2019)

Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice
por: Merk, Verena M., et al.
Publicado: (2023)

11β‐Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
por: Hardy, Rowan S, et al.
Publicado: (2016)

DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system
por: Juarez, Maria, et al.
Publicado: (2016)

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids
por: Fenton, Chloe, et al.
Publicado: (2021)

Glucocorticoid-Induced Osteoporosis – A Disorder of Mesenchymal Stromal Cells?
por: Hardy, Rowan, et al.
Publicado: (2011)

The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis
por: Cader, Mohammed Z, et al.
Publicado: (2010)

SAT276 Glucocorticoid Excess Elevates Metabolic Rate Via A 11b-HSD1 Dependent Mechanism In C57BL/6J Mice
por: Heaselgrave, Samuel, et al.
Publicado: (2023)

Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis
por: Raza, Karim, et al.
Publicado: (2016)

Vitamin D and early rheumatoid arthritis
por: Harrison, Stephanie R., et al.
Publicado: (2020)

Glucocorticoids and 11β-HSD1 are major regulators of intramyocellular protein metabolism
por: Morgan, Stuart A, et al.
Publicado: (2016)

Identification of novel antiacetylated vimentin antibodies in patients with early inflammatory arthritis
por: Juarez, Maria, et al.
Publicado: (2016)

Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe
por: Martin, Claire S., et al.
Publicado: (2021)

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint
por: Jeffery, Louisa E., et al.
Publicado: (2018)

11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation
por: Fenton, Chloe G, et al.
Publicado: (2022)

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
por: Karouzakis, Emmanuel, et al.
Publicado: (2018)

11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy
por: Fenton, C. G., et al.
Publicado: (2019)

Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium
por: McGettrick, Helen M, et al.
Publicado: (2010)

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis
por: Yeo, Lorraine, et al.
Publicado: (2011)

Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis
por: Yeo, L, et al.
Publicado: (2015)

Stromal Transcriptional Profiles Reveal Hierarchies of Anatomical Site, Serum Response and Disease and Identify Disease Specific Pathways
por: Filer, Andrew, et al.
Publicado: (2015)

Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients
por: Casanova-Vallve, Nuria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5ad7gtdgu8di8k3tbrd066jsu7