Defective tumor necrosis factor release from Crohn's disease macrophages in response to toll-like receptor activation: Relationship to phenotype and genome-wide association susceptibility loci

BACKGROUND: Recent work provides evidence of a failure of acute inflammation in Crohn's disease (CD), and suggests that the primary defect operates at the level of the macrophage and cytokine release. Here we extend the characterization of the innate immune defect in CD by investigating the mac...

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Detalles Bibliográficos
Autores principales: Sewell, Gavin W, Rahman, Farooq Z, Levine, Adam P, Jostins, Luke, Smith, Philip J, Walker, Ann P, Bloom, Stuart L, Segal, Anthony W, Smith, Andrew M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Original Basic Science Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532612/
https://www.ncbi.nlm.nih.gov/pubmed/22434667
http://dx.doi.org/10.1002/ibd.22952

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