Cargando…

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis

SUMMARY: Background: In comparison to the classical isoforms of protein kinase C (PKC), the novel isoforms are thought to play minor or inhibitory roles in the regulation of platelet activation and thrombosis. OBJECTIVES: To measure the levels of PKCθ and PKCε and to investigate the phenotype of mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	UNSWORTH, A J, FINNEY, B A, NAVARRO-NUNEZ, L, SEVERIN, S, WATSON, S P, PEARS, C J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Platelets
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532618/ https://www.ncbi.nlm.nih.gov/pubmed/22812584 http://dx.doi.org/10.1111/j.1538-7836.2012.04857.x

Ejemplares similares

Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β
por: Moroi, A. J., et al.
Publicado: (2015)

PPARγ agonists negatively regulate αIIbβ3 integrin outside‐in signaling and platelet function through up‐regulation of protein kinase A activity
por: Unsworth, A. J., et al.
Publicado: (2017)

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6
por: van den Bosch, M T J, et al.
Publicado: (2014)

Protein kinase C and P2Y(12) take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets
por: Moore, S F, et al.
Publicado: (2014)

CLEC‐2‐dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP
por: Borgognone, A., et al.
Publicado: (2014)

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis
por: Sasikumar, P., et al.
Publicado: (2018)

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation
por: Dunster, Joanne L., et al.
Publicado: (2019)

Platelet endothelial cell adhesion molecule-1 regulates collagen-stimulated platelet function by modulating the association of phosphatidylinositol 3-kinase with Grb-2-associated binding protein-1 and linker for activation of T cells
por: Moraes, L A, et al.
Publicado: (2010)

Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders
por: Adler, Marcel, et al.
Publicado: (2019)

G protein–coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1
por: Downes, Kate, et al.
Publicado: (2022)

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity
por: Anel, Alberto, et al.
Publicado: (2012)

Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε
por: Kewalramani, Girish, et al.
Publicado: (2011)

Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling
por: Paoletti, R, et al.
Publicado: (2010)

A novel nonsense variant in TPM4 caused dominant macrothrombocytopenia, mild bleeding tendency and disrupted cytoskeleton remodeling
por: Marín‐Quílez, Ana, et al.
Publicado: (2022)

Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response
por: Pasalic, L., et al.
Publicado: (2018)

The Copenhagen founder variant GP1BA c.58T>G is the most frequent cause of inherited thrombocytopenia in Denmark
por: Leinøe, Eva, et al.
Publicado: (2021)

Novel Protein kinase C θ: Coronin 1A complex in T lymphocytes
por: Siegmund, Kerstin, et al.
Publicado: (2015)

SMIFH2 inhibition of platelets demonstrates a critical role for formin proteins in platelet cytoskeletal dynamics
por: Green, Hannah L. H., et al.
Publicado: (2020)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Protein disulfide isomerase‐A1 regulates intraplatelet reactive oxygen species–thromboxane A(2)‐dependent pathway in human platelets
por: Przyborowski, Kamil, et al.
Publicado: (2021)

Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation
por: Hall, Kellie J., et al.
Publicado: (2008)

Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?
por: Sutcliffe, Elissa L., et al.
Publicado: (2012)

Individual phosphatidylinositol transfer proteins have distinct functions that do not involve lipid transfer activity
por: Zhao, Liang, et al.
Publicado: (2023)

Increased expression of HIF2α during iron deficiency–associated megakaryocytic differentiation
por: Jimenez, K., et al.
Publicado: (2015)

Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency
por: van Asten, Ivar, et al.
Publicado: (2019)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
por: Flora, Gagan D., et al.
Publicado: (2023)

Protein Kinase C θ Regulates the Phenotype of Murine CD4(+) Th17 Cells
por: Wachowicz, Katarzyna, et al.
Publicado: (2014)

Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
por: Zhou, Jun, et al.
Publicado: (2015)

Use of next‐generation sequencing and candidate gene analysis to identify underlying defects in patients with inherited platelet function disorders
por: Leo, V. C., et al.
Publicado: (2015)

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets
por: Poulter, N. S., et al.
Publicado: (2017)

Antiprothrombin antibodies induce platelet activation: A possible explanation for anti‐FXa therapy failure in patients with antiphospholipid syndrome?
por: Chayoua, Walid, et al.
Publicado: (2021)

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
por: Jooss, Natalie J., et al.
Publicado: (2022)

Protein kinase Cε: an oncogene and emerging tumor biomarker
por: Gorin, Michael A, et al.
Publicado: (2009)

Protein Kinase C-ε Promotes EMT in Breast Cancer
por: Jain, Kirti, et al.
Publicado: (2014)

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression
por: Jain, Kirti, et al.
Publicado: (2014)

Protein Kinase C θ Affects Ca(2+) Mobilization and NFAT Activation in Primary Mouse T Cells
por: Pfeifhofer, Christa, et al.
Publicado: (2003)

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
por: Kaiser, Rainer, et al.
Publicado: (2022)

Expression pattern of Protein Kinase C ϵ during mouse embryogenesis
por: Carracedo, Sergio, et al.
Publicado: (2013)

Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells
por: Basu, Alakananda
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vkchevajptkb405oqb7653o39t