A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs

In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone tr...

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Autores principales: Shivakumar, P., Rani, M. Usha, Reddy, A. Gopala, Anjaneyulu, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532767/
https://www.ncbi.nlm.nih.gov/pubmed/23293460
http://dx.doi.org/10.4103/0971-6580.103656
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author Shivakumar, P.
Rani, M. Usha
Reddy, A. Gopala
Anjaneyulu, Y.
author_facet Shivakumar, P.
Rani, M. Usha
Reddy, A. Gopala
Anjaneyulu, Y.
author_sort Shivakumar, P.
collection PubMed
description In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.
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spelling pubmed-35327672013-01-04 A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs Shivakumar, P. Rani, M. Usha Reddy, A. Gopala Anjaneyulu, Y. Toxicol Int Original Article In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3532767/ /pubmed/23293460 http://dx.doi.org/10.4103/0971-6580.103656 Text en Copyright: © Toxicology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shivakumar, P.
Rani, M. Usha
Reddy, A. Gopala
Anjaneyulu, Y.
A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title_full A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title_fullStr A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title_full_unstemmed A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title_short A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs
title_sort study on the toxic effects of doxorubicin on the histology of certain organs
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532767/
https://www.ncbi.nlm.nih.gov/pubmed/23293460
http://dx.doi.org/10.4103/0971-6580.103656
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