Cargando…

Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial

BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological...

Descripción completa

Detalles Bibliográficos
Autores principales: Pradeep, A. R., Agarwal, Esha, Bajaj, Pavan, Naik, Savitha B., Kumari, Minal, Guruprasad, C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532786/
https://www.ncbi.nlm.nih.gov/pubmed/23293479
http://dx.doi.org/10.4103/0976-237X.103616
_version_ 1782254346447093760
author Pradeep, A. R.
Agarwal, Esha
Bajaj, Pavan
Naik, Savitha B.
Kumari, Minal
Guruprasad, C. N.
author_facet Pradeep, A. R.
Agarwal, Esha
Bajaj, Pavan
Naik, Savitha B.
Kumari, Minal
Guruprasad, C. N.
author_sort Pradeep, A. R.
collection PubMed
description BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis. MATERIALS AND METHODS: Ninety subjects diagnosed with chronic generalized gingivitis were selected and randomly divided in three groups: Group 1 – placebo toothpaste, Group 2 – AF containing toothpaste, and Group 3 – triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire. RESULTS: AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste. CONCLUSIONS: AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health.
format Online
Article
Text
id pubmed-3532786
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-35327862013-01-04 Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial Pradeep, A. R. Agarwal, Esha Bajaj, Pavan Naik, Savitha B. Kumari, Minal Guruprasad, C. N. Contemp Clin Dent Original Article BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis. MATERIALS AND METHODS: Ninety subjects diagnosed with chronic generalized gingivitis were selected and randomly divided in three groups: Group 1 – placebo toothpaste, Group 2 – AF containing toothpaste, and Group 3 – triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire. RESULTS: AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste. CONCLUSIONS: AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3532786/ /pubmed/23293479 http://dx.doi.org/10.4103/0976-237X.103616 Text en Copyright: © Contemporary Clinical Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pradeep, A. R.
Agarwal, Esha
Bajaj, Pavan
Naik, Savitha B.
Kumari, Minal
Guruprasad, C. N.
Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title_full Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title_fullStr Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title_full_unstemmed Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title_short Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
title_sort clinical and microbiological effects of commercially available dentifrice containing amine fluoride: a randomized controlled clinical trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532786/
https://www.ncbi.nlm.nih.gov/pubmed/23293479
http://dx.doi.org/10.4103/0976-237X.103616
work_keys_str_mv AT pradeepar clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial
AT agarwalesha clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial
AT bajajpavan clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial
AT naiksavithab clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial
AT kumariminal clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial
AT guruprasadcn clinicalandmicrobiologicaleffectsofcommerciallyavailabledentifricecontainingaminefluoridearandomizedcontrolledclinicaltrial