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Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial
BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532786/ https://www.ncbi.nlm.nih.gov/pubmed/23293479 http://dx.doi.org/10.4103/0976-237X.103616 |
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author | Pradeep, A. R. Agarwal, Esha Bajaj, Pavan Naik, Savitha B. Kumari, Minal Guruprasad, C. N. |
author_facet | Pradeep, A. R. Agarwal, Esha Bajaj, Pavan Naik, Savitha B. Kumari, Minal Guruprasad, C. N. |
author_sort | Pradeep, A. R. |
collection | PubMed |
description | BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis. MATERIALS AND METHODS: Ninety subjects diagnosed with chronic generalized gingivitis were selected and randomly divided in three groups: Group 1 – placebo toothpaste, Group 2 – AF containing toothpaste, and Group 3 – triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire. RESULTS: AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste. CONCLUSIONS: AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health. |
format | Online Article Text |
id | pubmed-3532786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-35327862013-01-04 Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial Pradeep, A. R. Agarwal, Esha Bajaj, Pavan Naik, Savitha B. Kumari, Minal Guruprasad, C. N. Contemp Clin Dent Original Article BACKGROUND: The inability of the normal adult population to perform adequate tooth brushing has led to the search for chemotherapeutic agents in order to improve plaque control. This 6 month, single center, randomized controlled clinical trial was conducted to assess the clinical and microbiological effects of a dentifrice containing only amine fluoride (AF) as the active ingredient on gingivitis. MATERIALS AND METHODS: Ninety subjects diagnosed with chronic generalized gingivitis were selected and randomly divided in three groups: Group 1 – placebo toothpaste, Group 2 – AF containing toothpaste, and Group 3 – triclosan containing toothpaste with polymer and fluoride. Clinical evaluation was undertaken using the gingival index of Loe and Silness and the plaque index and microbiological counts were assessed at baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also undertaken by a questionnaire. RESULTS: AF containing toothpaste showed significant improvement in gingival and plaque index scores as well as microbiologic counts compared with placebo dentifrice. These improvements were comparable to triclosan containing toothpaste. CONCLUSIONS: AF containing toothpaste may be a useful formulation for chemical plaque control agent and improvement in plaque and gingival status and add to the list of various therapeutic agents used for maintenance of gingival health. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3532786/ /pubmed/23293479 http://dx.doi.org/10.4103/0976-237X.103616 Text en Copyright: © Contemporary Clinical Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Pradeep, A. R. Agarwal, Esha Bajaj, Pavan Naik, Savitha B. Kumari, Minal Guruprasad, C. N. Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title | Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title_full | Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title_fullStr | Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title_full_unstemmed | Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title_short | Clinical and microbiological effects of commercially available dentifrice containing amine fluoride: A randomized controlled clinical trial |
title_sort | clinical and microbiological effects of commercially available dentifrice containing amine fluoride: a randomized controlled clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532786/ https://www.ncbi.nlm.nih.gov/pubmed/23293479 http://dx.doi.org/10.4103/0976-237X.103616 |
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