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Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins

Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-l...

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Autores principales: Pinot de Moira, Angela, Sousa-Figueiredo, Jose C., Jones, Frances M., Fitzsimmons, Colin M., Betson, Martha, Kabatereine, Narcis B., Stothard, J. Russell, Dunne, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532835/
https://www.ncbi.nlm.nih.gov/pubmed/23125445
http://dx.doi.org/10.1093/infdis/jis676
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author Pinot de Moira, Angela
Sousa-Figueiredo, Jose C.
Jones, Frances M.
Fitzsimmons, Colin M.
Betson, Martha
Kabatereine, Narcis B.
Stothard, J. Russell
Dunne, David W.
author_facet Pinot de Moira, Angela
Sousa-Figueiredo, Jose C.
Jones, Frances M.
Fitzsimmons, Colin M.
Betson, Martha
Kabatereine, Narcis B.
Stothard, J. Russell
Dunne, David W.
author_sort Pinot de Moira, Angela
collection PubMed
description Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.
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spelling pubmed-35328352012-12-31 Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins Pinot de Moira, Angela Sousa-Figueiredo, Jose C. Jones, Frances M. Fitzsimmons, Colin M. Betson, Martha Kabatereine, Narcis B. Stothard, J. Russell Dunne, David W. J Infect Dis Major Articles and Brief Reports Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG(4)) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG(4)-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses. Oxford University Press 2013-01-15 2012-11-02 /pmc/articles/PMC3532835/ /pubmed/23125445 http://dx.doi.org/10.1093/infdis/jis676 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Major Articles and Brief Reports
Pinot de Moira, Angela
Sousa-Figueiredo, Jose C.
Jones, Frances M.
Fitzsimmons, Colin M.
Betson, Martha
Kabatereine, Narcis B.
Stothard, J. Russell
Dunne, David W.
Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title_full Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title_fullStr Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title_full_unstemmed Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title_short Schistosoma mansoni Infection in Preschool-Aged Children: Development of Immunoglobulin E and Immunoglobulin G(4) Responses to Parasite Allergen-Like Proteins
title_sort schistosoma mansoni infection in preschool-aged children: development of immunoglobulin e and immunoglobulin g(4) responses to parasite allergen-like proteins
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532835/
https://www.ncbi.nlm.nih.gov/pubmed/23125445
http://dx.doi.org/10.1093/infdis/jis676
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