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Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study
BACKGROUND: Low serum levels of 25-hydroxyvitamin D(3) are associated with an increased risk of respiratory tract infections (RTIs). Clinical trials with vitamin D(3) against various infections have been carried out but data are so far not conclusive. Thus, there is a need for additional randomised...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533016/ https://www.ncbi.nlm.nih.gov/pubmed/23242238 http://dx.doi.org/10.1136/bmjopen-2012-001663 |
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author | Bergman, Peter Norlin, Anna-Carin Hansen, Susanne Rekha, Rokeya Sultana Agerberth, Birgitta Björkhem-Bergman, Linda Ekström, Lena Lindh, Jonatan D Andersson, Jan |
author_facet | Bergman, Peter Norlin, Anna-Carin Hansen, Susanne Rekha, Rokeya Sultana Agerberth, Birgitta Björkhem-Bergman, Linda Ekström, Lena Lindh, Jonatan D Andersson, Jan |
author_sort | Bergman, Peter |
collection | PubMed |
description | BACKGROUND: Low serum levels of 25-hydroxyvitamin D(3) are associated with an increased risk of respiratory tract infections (RTIs). Clinical trials with vitamin D(3) against various infections have been carried out but data are so far not conclusive. Thus, there is a need for additional randomised controlled trials of effects of vitamin D(3) on infections. OBJECTIVE: To investigate if supplementation with vitamin D(3) could reduce infectious symptoms and antibiotic consumption among patients with antibody deficiency or frequent RTIs. DESIGN: A double-blind randomised controlled trial. SETTING: Karolinska University Hospital, Huddinge. PARTICIPANTS: 140 patients with antibody deficiency (selective IgA subclass deficiency, IgG subclass deficiency, common variable immune disorder) and patients with increased susceptibility to RTIs (>4 bacterial RTIs/year) but without immunological diagnosis. INTERVENTION: Vitamin D(3) (4000 IU) or placebo was given daily for 1 year. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary endpoint was an infectious score based on five parameters: symptoms from respiratory tract, ears and sinuses, malaise and antibiotic consumption. Secondary endpoints were serum levels of 25-hydroxyvitamin D(3), microbiological findings and levels of antimicrobial peptides (LL-37, HNP1–3) in nasal fluid. RESULTS: The overall infectious score was significantly reduced for patients allocated to the vitamin D group (202 points) compared with the placebo group (249 points; adjusted relative score 0.771, 95% CI 0.604 to 0.985, p=0.04). LIMITATIONS: A single study centre, small sample size and a selected group of patients. The sample size calculation was performed using p=0.02 as the significance level whereas the primary and secondary endpoints were analysed using the conventional p=0.05 as the significance level. CONCLUSIONS: Supplementation with vitamin D(3) may reduce disease burden in patients with frequent RTIs. |
format | Online Article Text |
id | pubmed-3533016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-35330162013-01-04 Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study Bergman, Peter Norlin, Anna-Carin Hansen, Susanne Rekha, Rokeya Sultana Agerberth, Birgitta Björkhem-Bergman, Linda Ekström, Lena Lindh, Jonatan D Andersson, Jan BMJ Open Infectious Diseases BACKGROUND: Low serum levels of 25-hydroxyvitamin D(3) are associated with an increased risk of respiratory tract infections (RTIs). Clinical trials with vitamin D(3) against various infections have been carried out but data are so far not conclusive. Thus, there is a need for additional randomised controlled trials of effects of vitamin D(3) on infections. OBJECTIVE: To investigate if supplementation with vitamin D(3) could reduce infectious symptoms and antibiotic consumption among patients with antibody deficiency or frequent RTIs. DESIGN: A double-blind randomised controlled trial. SETTING: Karolinska University Hospital, Huddinge. PARTICIPANTS: 140 patients with antibody deficiency (selective IgA subclass deficiency, IgG subclass deficiency, common variable immune disorder) and patients with increased susceptibility to RTIs (>4 bacterial RTIs/year) but without immunological diagnosis. INTERVENTION: Vitamin D(3) (4000 IU) or placebo was given daily for 1 year. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary endpoint was an infectious score based on five parameters: symptoms from respiratory tract, ears and sinuses, malaise and antibiotic consumption. Secondary endpoints were serum levels of 25-hydroxyvitamin D(3), microbiological findings and levels of antimicrobial peptides (LL-37, HNP1–3) in nasal fluid. RESULTS: The overall infectious score was significantly reduced for patients allocated to the vitamin D group (202 points) compared with the placebo group (249 points; adjusted relative score 0.771, 95% CI 0.604 to 0.985, p=0.04). LIMITATIONS: A single study centre, small sample size and a selected group of patients. The sample size calculation was performed using p=0.02 as the significance level whereas the primary and secondary endpoints were analysed using the conventional p=0.05 as the significance level. CONCLUSIONS: Supplementation with vitamin D(3) may reduce disease burden in patients with frequent RTIs. BMJ Publishing Group 2012-12-13 /pmc/articles/PMC3533016/ /pubmed/23242238 http://dx.doi.org/10.1136/bmjopen-2012-001663 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Infectious Diseases Bergman, Peter Norlin, Anna-Carin Hansen, Susanne Rekha, Rokeya Sultana Agerberth, Birgitta Björkhem-Bergman, Linda Ekström, Lena Lindh, Jonatan D Andersson, Jan Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title | Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title_full | Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title_fullStr | Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title_full_unstemmed | Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title_short | Vitamin D(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
title_sort | vitamin d(3) supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study |
topic | Infectious Diseases |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533016/ https://www.ncbi.nlm.nih.gov/pubmed/23242238 http://dx.doi.org/10.1136/bmjopen-2012-001663 |
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