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SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells

Activation of SIRT1, an NAD+-dependent deacetylase, prevents retinal ganglion cell (RGC) loss in optic neuritis, an inflammatory demyelinating optic nerve disease. While SIRT1 deacetylates numerous protein targets, downstream mechanisms of SIRT1 activation mediating this neuroprotective effect are u...

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Detalles Bibliográficos
Autores principales:	Khan, Reas S., Fonseca-Kelly, Zoe, Callinan, Catherine, Zuo, Ling, Sachdeva, Mira M., Shindler, Kenneth S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533205/ https://www.ncbi.nlm.nih.gov/pubmed/23293585 http://dx.doi.org/10.3389/fncel.2012.00063

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