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Telomeres and viruses: common themes of genome maintenance

Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance. Viruses have their own specialized strategies for genome maintenance, which can mimic and modify host...

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Detalles Bibliográficos
Autores principales: Deng, Zhong, Wang, Zhuo, Lieberman, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533235/
https://www.ncbi.nlm.nih.gov/pubmed/23293769
http://dx.doi.org/10.3389/fonc.2012.00201
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author Deng, Zhong
Wang, Zhuo
Lieberman, Paul M.
author_facet Deng, Zhong
Wang, Zhuo
Lieberman, Paul M.
author_sort Deng, Zhong
collection PubMed
description Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance. Viruses have their own specialized strategies for genome maintenance, which can mimic and modify host cell processes. Here, we review some of the common features of genome maintenance utilized by viruses and host chromosomes, with a particular focus on terminal repeat (TR) elements. The TRs of cellular chromosomes, better known as telomeres, have well-established roles in cellular chromosome stability. Cellular telomeres are themselves maintained by viral-like mechanisms, including self-propagation by reverse transcription, recombination, and retrotransposition. Viral TR elements, like cellular telomeres, are essential for viral genome stability and propagation. We review the structure and function of viral repeat elements and discuss how they may share telomere-like structures and genome protection functions. We consider how viral infections modulate telomere regulatory factors for viral repurposing and can alter normal host telomere structure and chromosome stability. Understanding the common strategies of viral and cellular genome maintenance may provide new insights into viral–host interactions and the mechanisms driving genetic instability in cancer.
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spelling pubmed-35332352013-01-04 Telomeres and viruses: common themes of genome maintenance Deng, Zhong Wang, Zhuo Lieberman, Paul M. Front Oncol Oncology Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance. Viruses have their own specialized strategies for genome maintenance, which can mimic and modify host cell processes. Here, we review some of the common features of genome maintenance utilized by viruses and host chromosomes, with a particular focus on terminal repeat (TR) elements. The TRs of cellular chromosomes, better known as telomeres, have well-established roles in cellular chromosome stability. Cellular telomeres are themselves maintained by viral-like mechanisms, including self-propagation by reverse transcription, recombination, and retrotransposition. Viral TR elements, like cellular telomeres, are essential for viral genome stability and propagation. We review the structure and function of viral repeat elements and discuss how they may share telomere-like structures and genome protection functions. We consider how viral infections modulate telomere regulatory factors for viral repurposing and can alter normal host telomere structure and chromosome stability. Understanding the common strategies of viral and cellular genome maintenance may provide new insights into viral–host interactions and the mechanisms driving genetic instability in cancer. Frontiers Media S.A. 2012-12-31 /pmc/articles/PMC3533235/ /pubmed/23293769 http://dx.doi.org/10.3389/fonc.2012.00201 Text en Copyright © Deng, Wang and Lieberman. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Deng, Zhong
Wang, Zhuo
Lieberman, Paul M.
Telomeres and viruses: common themes of genome maintenance
title Telomeres and viruses: common themes of genome maintenance
title_full Telomeres and viruses: common themes of genome maintenance
title_fullStr Telomeres and viruses: common themes of genome maintenance
title_full_unstemmed Telomeres and viruses: common themes of genome maintenance
title_short Telomeres and viruses: common themes of genome maintenance
title_sort telomeres and viruses: common themes of genome maintenance
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533235/
https://www.ncbi.nlm.nih.gov/pubmed/23293769
http://dx.doi.org/10.3389/fonc.2012.00201
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