Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations

RNA is an important therapeutic target but information about RNA-ligand interactions is limited. Here we report a screening method that probes over 3,000,000 combinations of RNA motif-small molecule interactions to identify the privileged RNA structures and chemical spaces that interact. Specificall...

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Detalles Bibliográficos
Autores principales: Tran, Tuan, Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533436/
https://www.ncbi.nlm.nih.gov/pubmed/23047683
http://dx.doi.org/10.1038/ncomms2119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533436/
https://www.ncbi.nlm.nih.gov/pubmed/23047683
http://dx.doi.org/10.1038/ncomms2119

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