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Identifying the Preferred RNA Motifs and Chemotypes that Interact by Probing Millions of Combinations
RNA is an important therapeutic target but information about RNA-ligand interactions is limited. Here we report a screening method that probes over 3,000,000 combinations of RNA motif-small molecule interactions to identify the privileged RNA structures and chemical spaces that interact. Specificall...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533436/ https://www.ncbi.nlm.nih.gov/pubmed/23047683 http://dx.doi.org/10.1038/ncomms2119 |