Cargando…
Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation
Heat shock proteins (Hsp) play critical roles in the body's self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular proteins. Exercise increases the levels of Hsp through elevat...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533452/ https://www.ncbi.nlm.nih.gov/pubmed/23304460 http://dx.doi.org/10.1155/2012/836519 |
_version_ | 1782254414760771584 |
---|---|
author | Noble, Earl G. Shen, Garry X. |
author_facet | Noble, Earl G. Shen, Garry X. |
author_sort | Noble, Earl G. |
collection | PubMed |
description | Heat shock proteins (Hsp) play critical roles in the body's self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular proteins. Exercise increases the levels of Hsp through elevated temperature, hormones, calcium fluxes, reactive oxygen species (ROS), or mechanical deformation of tissues. Isotonic contractions and endurance- type activities tend to increase Hsp60 and Hsp70. Eccentric muscle contractions lead to phosphorylation and translocation of Hsp25/27. Exercise-induced transient increases of Hsp inhibit the generation of inflammatory mediators and vascular inflammation. Metabolic disorders (hyperglycemia and dyslipidemia) are associated with type 1 diabetes (an autoimmune disease), type 2 diabetes (the common type of diabetes usually associated with obesity), and atherosclerotic cardiovascular disease. Metabolic disorders activate HSF/Hsp pathway, which was associated with oxidative stress, increased generation of inflammatory mediators, vascular inflammation, and cell injury. Knock down of heat shock factor-1 (HSF1) reduced the activation of key inflammatory mediators in vascular cells. Accumulating lines of evidence suggest that the activation of HSF/Hsp induced by exercise or metabolic disorders may play a dual role in inflammation. The benefits of exercise on inflammation and metabolism depend on the type, intensity, and duration of physical activity. |
format | Online Article Text |
id | pubmed-3533452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-35334522013-01-09 Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation Noble, Earl G. Shen, Garry X. Autoimmune Dis Review Article Heat shock proteins (Hsp) play critical roles in the body's self-defense under a variety of stresses, including heat shock, oxidative stress, radiation, and wounds, through the regulation of folding and functions of relevant cellular proteins. Exercise increases the levels of Hsp through elevated temperature, hormones, calcium fluxes, reactive oxygen species (ROS), or mechanical deformation of tissues. Isotonic contractions and endurance- type activities tend to increase Hsp60 and Hsp70. Eccentric muscle contractions lead to phosphorylation and translocation of Hsp25/27. Exercise-induced transient increases of Hsp inhibit the generation of inflammatory mediators and vascular inflammation. Metabolic disorders (hyperglycemia and dyslipidemia) are associated with type 1 diabetes (an autoimmune disease), type 2 diabetes (the common type of diabetes usually associated with obesity), and atherosclerotic cardiovascular disease. Metabolic disorders activate HSF/Hsp pathway, which was associated with oxidative stress, increased generation of inflammatory mediators, vascular inflammation, and cell injury. Knock down of heat shock factor-1 (HSF1) reduced the activation of key inflammatory mediators in vascular cells. Accumulating lines of evidence suggest that the activation of HSF/Hsp induced by exercise or metabolic disorders may play a dual role in inflammation. The benefits of exercise on inflammation and metabolism depend on the type, intensity, and duration of physical activity. Hindawi Publishing Corporation 2012 2012-12-17 /pmc/articles/PMC3533452/ /pubmed/23304460 http://dx.doi.org/10.1155/2012/836519 Text en Copyright © 2012 E. G. Noble and G. X. Shen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Noble, Earl G. Shen, Garry X. Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title | Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title_full | Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title_fullStr | Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title_full_unstemmed | Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title_short | Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation |
title_sort | impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533452/ https://www.ncbi.nlm.nih.gov/pubmed/23304460 http://dx.doi.org/10.1155/2012/836519 |
work_keys_str_mv | AT nobleearlg impactofexerciseandmetabolicdisordersonheatshockproteinsandvascularinflammation AT shengarryx impactofexerciseandmetabolicdisordersonheatshockproteinsandvascularinflammation |