Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with ant...

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Detalles Bibliográficos
Autores principales: Kebir, Sied, Kuchelmeister, Klaus, Niehusmann, Pitt, Nelles, Michael, Kim, Young, Thanendrarajan, Sharmilan, Schäfer, Niklas, Stuplich, Moritz, Mack, Frederic, Scheffler, Björn, Urbach, Horst, Glas, Martin, Herrlinger, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533508/
https://www.ncbi.nlm.nih.gov/pubmed/23217063
http://dx.doi.org/10.1186/2162-3619-1-37
Descripción
Sumario:Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.

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