Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with ant...

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Autores principales: Kebir, Sied, Kuchelmeister, Klaus, Niehusmann, Pitt, Nelles, Michael, Kim, Young, Thanendrarajan, Sharmilan, Schäfer, Niklas, Stuplich, Moritz, Mack, Frederic, Scheffler, Björn, Urbach, Horst, Glas, Martin, Herrlinger, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533508/
https://www.ncbi.nlm.nih.gov/pubmed/23217063
http://dx.doi.org/10.1186/2162-3619-1-37
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author Kebir, Sied
Kuchelmeister, Klaus
Niehusmann, Pitt
Nelles, Michael
Kim, Young
Thanendrarajan, Sharmilan
Schäfer, Niklas
Stuplich, Moritz
Mack, Frederic
Scheffler, Björn
Urbach, Horst
Glas, Martin
Herrlinger, Ulrich
author_facet Kebir, Sied
Kuchelmeister, Klaus
Niehusmann, Pitt
Nelles, Michael
Kim, Young
Thanendrarajan, Sharmilan
Schäfer, Niklas
Stuplich, Moritz
Mack, Frederic
Scheffler, Björn
Urbach, Horst
Glas, Martin
Herrlinger, Ulrich
author_sort Kebir, Sied
collection PubMed
description Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.
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spelling pubmed-35335082013-01-03 Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy Kebir, Sied Kuchelmeister, Klaus Niehusmann, Pitt Nelles, Michael Kim, Young Thanendrarajan, Sharmilan Schäfer, Niklas Stuplich, Moritz Mack, Frederic Scheffler, Björn Urbach, Horst Glas, Martin Herrlinger, Ulrich Exp Hematol Oncol Case Report Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis. BioMed Central 2012-12-05 /pmc/articles/PMC3533508/ /pubmed/23217063 http://dx.doi.org/10.1186/2162-3619-1-37 Text en Copyright ©2012 Kebir et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kebir, Sied
Kuchelmeister, Klaus
Niehusmann, Pitt
Nelles, Michael
Kim, Young
Thanendrarajan, Sharmilan
Schäfer, Niklas
Stuplich, Moritz
Mack, Frederic
Scheffler, Björn
Urbach, Horst
Glas, Martin
Herrlinger, Ulrich
Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title_full Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title_fullStr Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title_full_unstemmed Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title_short Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
title_sort intravascular cns lymphoma: successful therapy using high-dose methotrexate-based polychemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533508/
https://www.ncbi.nlm.nih.gov/pubmed/23217063
http://dx.doi.org/10.1186/2162-3619-1-37
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