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Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE)

BACKGROUND: The inhibition of the activity of β-secretase (BACE-1) is a potentially important approach for the treatment of Alzheimer disease. To explore the mechanism of inhibition, we describe the use of 46 X-ray crystallographic BACE-1/inhibitor complexes to derive quantitative structure-activity...

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Detalles Bibliográficos
Autores principales:	Liu, Shu, Fu, Rao, Cheng, Xiao, Chen, Sheng-Ping, Zhou, Li-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533579/ https://www.ncbi.nlm.nih.gov/pubmed/22925713 http://dx.doi.org/10.1186/1472-6807-12-21

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