LKB1 and AMP-activated protein kinase: regulators of cell polarity

Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polar...

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Detalles Bibliográficos
Autores principales: Nakano, Atsushi, Takashima, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533759/
https://www.ncbi.nlm.nih.gov/pubmed/22892070
http://dx.doi.org/10.1111/j.1365-2443.2012.01629.x
Descripción
Sumario:Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.

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