LKB1 and AMP-activated protein kinase: regulators of cell polarity

Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polar...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakano, Atsushi, Takashima, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533759/
https://www.ncbi.nlm.nih.gov/pubmed/22892070
http://dx.doi.org/10.1111/j.1365-2443.2012.01629.x
_version_ 1782254450209980416
author Nakano, Atsushi
Takashima, Seiji
author_facet Nakano, Atsushi
Takashima, Seiji
author_sort Nakano, Atsushi
collection PubMed
description Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity.
format Online
Article
Text
id pubmed-3533759
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-35337592013-01-08 LKB1 and AMP-activated protein kinase: regulators of cell polarity Nakano, Atsushi Takashima, Seiji Genes Cells Review Adenosine monophosphate–activated protein kinase (AMPK), a metabolic protein kinase, and its upstream kinase LKB1 play crucial roles in the establishment and maintenance of cell polarity. Although the shapes of polarized cells display extraordinary diversity, the key molecules involved in cell polarity are relatively well conserved. Here, we review the mechanisms and factors responsible for organizing cell polarity and the role of LKB1 and AMPK in cell polarity. Blackwell Publishing Ltd 2012-09 2012-08-14 /pmc/articles/PMC3533759/ /pubmed/22892070 http://dx.doi.org/10.1111/j.1365-2443.2012.01629.x Text en © 2012 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review
Nakano, Atsushi
Takashima, Seiji
LKB1 and AMP-activated protein kinase: regulators of cell polarity
title LKB1 and AMP-activated protein kinase: regulators of cell polarity
title_full LKB1 and AMP-activated protein kinase: regulators of cell polarity
title_fullStr LKB1 and AMP-activated protein kinase: regulators of cell polarity
title_full_unstemmed LKB1 and AMP-activated protein kinase: regulators of cell polarity
title_short LKB1 and AMP-activated protein kinase: regulators of cell polarity
title_sort lkb1 and amp-activated protein kinase: regulators of cell polarity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533759/
https://www.ncbi.nlm.nih.gov/pubmed/22892070
http://dx.doi.org/10.1111/j.1365-2443.2012.01629.x
work_keys_str_mv AT nakanoatsushi lkb1andampactivatedproteinkinaseregulatorsofcellpolarity
AT takashimaseiji lkb1andampactivatedproteinkinaseregulatorsofcellpolarity

Ejemplares similares