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Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine-Containing Substrates

Fluorine is commonly applied in pharmaceuticals to block the degradation of bioactive compounds at a specific site of the molecule. Blocking of the reaction center of the enzyme-catalyzed ring closure of 1,2,3,4-tetrahydrobenzylisoquinolines by a fluoro moiety allowed redirecting the berberine bridg...

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Detalles Bibliográficos
Autores principales:	Resch, Verena, Lechner, Horst, Schrittwieser, Joerg H, Wallner, Silvia, Gruber, Karl, Macheroux, Peter, Kroutil, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533790/ https://www.ncbi.nlm.nih.gov/pubmed/22962029 http://dx.doi.org/10.1002/chem.201201895

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