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The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer
BACKGROUND: Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to evaluate the incidence and the survival impact of preexisti...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533895/ https://www.ncbi.nlm.nih.gov/pubmed/22553992 http://dx.doi.org/10.1186/1477-7819-10-76 |
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author | Huang, Ching-Wen Sun, Li-Chu Shih, Ying-Ling Tsai, Hsiang-Lin Chen, Chao-Wen Yeh, Yung-Sung Ma, Cheng-Jen Huang, Che-Jen Wang, Jaw-Yuan |
author_facet | Huang, Ching-Wen Sun, Li-Chu Shih, Ying-Ling Tsai, Hsiang-Lin Chen, Chao-Wen Yeh, Yung-Sung Ma, Cheng-Jen Huang, Che-Jen Wang, Jaw-Yuan |
author_sort | Huang, Ching-Wen |
collection | PubMed |
description | BACKGROUND: Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to evaluate the incidence and the survival impact of preexisting DM on the long-term outcomes of patients with CRC in Taiwan. METHODS: From January 2002 to December 2008, 1,197 consecutive patients with histologically proven primary CRC, who received surgical treatment at a single institution, were enrolled. The clinicopathologic features between these patients with and without DM were retrospectively investigated. Moreover, we intended to analyze the impact of DM on overall survival (OS) and cancer-specific survival (CSS) rates. RESULTS: Of 1,197 CRC patients, 23.6% of patients had either a reported history of DM or were currently taking one or more diabetes-controlling medications. CRC patients with DM were significantly older than those without DM (P < 0.001), and had a higher incidence of cardiac disease and higher body mass index than those without DM (both P < 0.001). There were no significant differences in gender, tumor size, tumor location, histological type, AJCC/UICC cancer stage, vascular invasion, perineural invasion, comorbidity of pulmonary disease or renal disease, and OS, and CSS between two groups. Additionally, DM patients had a higher incidence of second malignancy than patients without DM (9.54% vs 6.01%, P = 0.040). CONCLUSIONS: A considerably high prevalence of DM in CRC patients but no significant impact of DM on survival was observed in the single-institution retrospective study, regardless of cancer stages and tumor locations. Therefore, treatment strategies for CRC patients with DM should be the same as patients without DM. |
format | Online Article Text |
id | pubmed-3533895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35338952013-01-07 The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer Huang, Ching-Wen Sun, Li-Chu Shih, Ying-Ling Tsai, Hsiang-Lin Chen, Chao-Wen Yeh, Yung-Sung Ma, Cheng-Jen Huang, Che-Jen Wang, Jaw-Yuan World J Surg Oncol Research BACKGROUND: Both colorectal cancer (CRC) and diabetes mellitus (DM) are important public health problems worldwide. As there are controversies about survival impact on CRC patients with preexisting DM, the purpose of the present study is to evaluate the incidence and the survival impact of preexisting DM on the long-term outcomes of patients with CRC in Taiwan. METHODS: From January 2002 to December 2008, 1,197 consecutive patients with histologically proven primary CRC, who received surgical treatment at a single institution, were enrolled. The clinicopathologic features between these patients with and without DM were retrospectively investigated. Moreover, we intended to analyze the impact of DM on overall survival (OS) and cancer-specific survival (CSS) rates. RESULTS: Of 1,197 CRC patients, 23.6% of patients had either a reported history of DM or were currently taking one or more diabetes-controlling medications. CRC patients with DM were significantly older than those without DM (P < 0.001), and had a higher incidence of cardiac disease and higher body mass index than those without DM (both P < 0.001). There were no significant differences in gender, tumor size, tumor location, histological type, AJCC/UICC cancer stage, vascular invasion, perineural invasion, comorbidity of pulmonary disease or renal disease, and OS, and CSS between two groups. Additionally, DM patients had a higher incidence of second malignancy than patients without DM (9.54% vs 6.01%, P = 0.040). CONCLUSIONS: A considerably high prevalence of DM in CRC patients but no significant impact of DM on survival was observed in the single-institution retrospective study, regardless of cancer stages and tumor locations. Therefore, treatment strategies for CRC patients with DM should be the same as patients without DM. BioMed Central 2012-05-03 /pmc/articles/PMC3533895/ /pubmed/22553992 http://dx.doi.org/10.1186/1477-7819-10-76 Text en Copyright ©2012 Huang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Huang, Ching-Wen Sun, Li-Chu Shih, Ying-Ling Tsai, Hsiang-Lin Chen, Chao-Wen Yeh, Yung-Sung Ma, Cheng-Jen Huang, Che-Jen Wang, Jaw-Yuan The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title_full | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title_fullStr | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title_full_unstemmed | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title_short | The impact on clinical outcome of high prevalence of diabetes mellitus in Taiwanese patients with colorectal cancer |
title_sort | impact on clinical outcome of high prevalence of diabetes mellitus in taiwanese patients with colorectal cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533895/ https://www.ncbi.nlm.nih.gov/pubmed/22553992 http://dx.doi.org/10.1186/1477-7819-10-76 |
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