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PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation
BACKGROUND: Parkinson disease (PD) is characterized by a slow, progressive degeneration of dopaminergic neurons in the substantianigra. The cause of neuronal loss in PD is not well understood, but several genetic loci, including PTEN-induced putative kinase 1 (PINK1), have been linked to early-onset...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533909/ https://www.ncbi.nlm.nih.gov/pubmed/23244239 http://dx.doi.org/10.1186/1742-2094-9-271 |