Cargando…

Vldlr overexpression causes hyperactivity in rats

BACKGROUND: Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects and behavioral abnormalities. Several reports have implicated reelin signaling...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwata, Keiko, Izumo, Nobuo, Matsuzaki, Hideo, Manabe, Takayuki, Ishibashi, Yukiko, Ichitani, Yukio, Yamada, Kazuo, Thanseem, Ismail, Anitha, Ayyappan, Vasu, Mahesh Mundalil, Shimmura, Chie, Wakuda, Tomoyasu, Kameno, Yosuke, Takahashi, Taro, Iwata, Yasuhide, Suzuki, Katsuaki, Nakamura, Kazuhiko, Mori, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533969/
https://www.ncbi.nlm.nih.gov/pubmed/23110844
http://dx.doi.org/10.1186/2040-2392-3-11
_version_ 1782254496964935680
author Iwata, Keiko
Izumo, Nobuo
Matsuzaki, Hideo
Manabe, Takayuki
Ishibashi, Yukiko
Ichitani, Yukio
Yamada, Kazuo
Thanseem, Ismail
Anitha, Ayyappan
Vasu, Mahesh Mundalil
Shimmura, Chie
Wakuda, Tomoyasu
Kameno, Yosuke
Takahashi, Taro
Iwata, Yasuhide
Suzuki, Katsuaki
Nakamura, Kazuhiko
Mori, Norio
author_facet Iwata, Keiko
Izumo, Nobuo
Matsuzaki, Hideo
Manabe, Takayuki
Ishibashi, Yukiko
Ichitani, Yukio
Yamada, Kazuo
Thanseem, Ismail
Anitha, Ayyappan
Vasu, Mahesh Mundalil
Shimmura, Chie
Wakuda, Tomoyasu
Kameno, Yosuke
Takahashi, Taro
Iwata, Yasuhide
Suzuki, Katsuaki
Nakamura, Kazuhiko
Mori, Norio
author_sort Iwata, Keiko
collection PubMed
description BACKGROUND: Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects and behavioral abnormalities. Several reports have implicated reelin signaling in the etiology of neurodevelopmental and psychiatric disorders, including autism, schizophrenia, bipolar disorder, and depression. Moreover, it has been reported that VLDLR mRNA levels are increased in the post-mortem brain of autistic patients. METHODS: We generated transgenic (Tg) rats overexpressing Vldlr, and examined their histological and behavioral features. RESULTS: Spontaneous locomotor activity was significantly increased in Tg rats, without detectable changes in brain histology. Additionally, Tg rats tended to show performance deficits in the radial maze task, suggesting that their spatial working memory was slightly impaired. Thus, Vldlr levels may be involved in determining locomotor activity and memory function. CONCLUSIONS: Unlike reeler mice, patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberrations. Therefore, it is notable, from a clinical point of view, that we observed behavioral phenotypes in Vldlr-Tg rats in the absence of neuroanatomical abnormalities.
format Online
Article
Text
id pubmed-3533969
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-35339692013-01-07 Vldlr overexpression causes hyperactivity in rats Iwata, Keiko Izumo, Nobuo Matsuzaki, Hideo Manabe, Takayuki Ishibashi, Yukiko Ichitani, Yukio Yamada, Kazuo Thanseem, Ismail Anitha, Ayyappan Vasu, Mahesh Mundalil Shimmura, Chie Wakuda, Tomoyasu Kameno, Yosuke Takahashi, Taro Iwata, Yasuhide Suzuki, Katsuaki Nakamura, Kazuhiko Mori, Norio Mol Autism Research BACKGROUND: Reelin regulates neuronal positioning in cortical brain structures and neuronal migration via binding to the lipoprotein receptors Vldlr and Lrp8. Reeler mutant mice display severe brain morphological defects and behavioral abnormalities. Several reports have implicated reelin signaling in the etiology of neurodevelopmental and psychiatric disorders, including autism, schizophrenia, bipolar disorder, and depression. Moreover, it has been reported that VLDLR mRNA levels are increased in the post-mortem brain of autistic patients. METHODS: We generated transgenic (Tg) rats overexpressing Vldlr, and examined their histological and behavioral features. RESULTS: Spontaneous locomotor activity was significantly increased in Tg rats, without detectable changes in brain histology. Additionally, Tg rats tended to show performance deficits in the radial maze task, suggesting that their spatial working memory was slightly impaired. Thus, Vldlr levels may be involved in determining locomotor activity and memory function. CONCLUSIONS: Unlike reeler mice, patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberrations. Therefore, it is notable, from a clinical point of view, that we observed behavioral phenotypes in Vldlr-Tg rats in the absence of neuroanatomical abnormalities. BioMed Central 2012-10-30 /pmc/articles/PMC3533969/ /pubmed/23110844 http://dx.doi.org/10.1186/2040-2392-3-11 Text en Copyright ©2012 Iwata et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Iwata, Keiko
Izumo, Nobuo
Matsuzaki, Hideo
Manabe, Takayuki
Ishibashi, Yukiko
Ichitani, Yukio
Yamada, Kazuo
Thanseem, Ismail
Anitha, Ayyappan
Vasu, Mahesh Mundalil
Shimmura, Chie
Wakuda, Tomoyasu
Kameno, Yosuke
Takahashi, Taro
Iwata, Yasuhide
Suzuki, Katsuaki
Nakamura, Kazuhiko
Mori, Norio
Vldlr overexpression causes hyperactivity in rats
title Vldlr overexpression causes hyperactivity in rats
title_full Vldlr overexpression causes hyperactivity in rats
title_fullStr Vldlr overexpression causes hyperactivity in rats
title_full_unstemmed Vldlr overexpression causes hyperactivity in rats
title_short Vldlr overexpression causes hyperactivity in rats
title_sort vldlr overexpression causes hyperactivity in rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533969/
https://www.ncbi.nlm.nih.gov/pubmed/23110844
http://dx.doi.org/10.1186/2040-2392-3-11
work_keys_str_mv AT iwatakeiko vldlroverexpressioncauseshyperactivityinrats
AT izumonobuo vldlroverexpressioncauseshyperactivityinrats
AT matsuzakihideo vldlroverexpressioncauseshyperactivityinrats
AT manabetakayuki vldlroverexpressioncauseshyperactivityinrats
AT ishibashiyukiko vldlroverexpressioncauseshyperactivityinrats
AT ichitaniyukio vldlroverexpressioncauseshyperactivityinrats
AT yamadakazuo vldlroverexpressioncauseshyperactivityinrats
AT thanseemismail vldlroverexpressioncauseshyperactivityinrats
AT anithaayyappan vldlroverexpressioncauseshyperactivityinrats
AT vasumaheshmundalil vldlroverexpressioncauseshyperactivityinrats
AT shimmurachie vldlroverexpressioncauseshyperactivityinrats
AT wakudatomoyasu vldlroverexpressioncauseshyperactivityinrats
AT kamenoyosuke vldlroverexpressioncauseshyperactivityinrats
AT takahashitaro vldlroverexpressioncauseshyperactivityinrats
AT iwatayasuhide vldlroverexpressioncauseshyperactivityinrats
AT suzukikatsuaki vldlroverexpressioncauseshyperactivityinrats
AT nakamurakazuhiko vldlroverexpressioncauseshyperactivityinrats
AT morinorio vldlroverexpressioncauseshyperactivityinrats