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Engineering HIV-1-Resistant T-Cells from Short-Hairpin RNA-Expressing Hematopoietic Stem/Progenitor Cells in Humanized BLT Mice

Down-regulation of the HIV-1 coreceptor CCR5 holds significant potential for long-term protection against HIV-1 in patients. Using the humanized bone marrow/liver/thymus (hu-BLT) mouse model which allows investigation of human hematopoietic stem/progenitor cell (HSPC) transplant and immune system re...

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Detalles Bibliográficos
Autores principales:	Ringpis, Gene-Errol E., Shimizu, Saki, Arokium, Hubert, Camba-Colón, Joanna, Carroll, Maria V., Cortado, Ruth, Xie, Yiming, Kim, Patrick Y., Sahakyan, Anna, Lowe, Emily L., Narukawa, Munetoshi, Kandarian, Fadi N., Burke, Bryan P., Symonds, Geoff P., An, Dong Sung, Chen, Irvin S. Y., Kamata, Masakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534037/ https://www.ncbi.nlm.nih.gov/pubmed/23300932 http://dx.doi.org/10.1371/journal.pone.0053492

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