Apolipoprotein E4 Causes Age- and Sex-Dependent Impairments of Hilar GABAergic Interneurons and Learning and Memory Deficits in Mice

Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease (AD). ApoE4 has sex-dependent effects, whereby the risk of developing AD is higher in apoE4-expressing females than males. However, the mechanism underlying the sex difference, in relation to apoE4, is unknown. Pre...

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Detalles Bibliográficos
Autores principales: Leung, Laura, Andrews-Zwilling, Yaisa, Yoon, Seo Yeon, Jain, Sachi, Ring, Karen, Dai, Jessica, Wang, Max Mu, Tong, Leslie, Walker, David, Huang, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534053/
https://www.ncbi.nlm.nih.gov/pubmed/23300939
http://dx.doi.org/10.1371/journal.pone.0053569

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