Cargando…

Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways

Increasing evidence suggests that obesity and aberrant proliferation of nucleus pulposus (NP) cells are associated with intervertebral disc degeneration. Leptin, a hormone with increased circulating level in obesity, has been shown to stimulate cell proliferation in a tissue-dependent manner. Nevert...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zheng, Shen, Jianxiong, Wu, William Ka Kei, Yu, Xin, Liang, Jinqian, Qiu, Guixing, Liu, Jiaming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534060/ https://www.ncbi.nlm.nih.gov/pubmed/23300886 http://dx.doi.org/10.1371/journal.pone.0053176

Ejemplares similares

The Role of Leptin on the Organization and Expression of Cytoskeleton Elements in Nucleus Pulposus Cells
por: Li, Zheng, et al.
Publicado: (2013)

Retraction: Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways
Publicado: (2023)

Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells
por: Li, Zheng, et al.
Publicado: (2014)

Leptin Activates RhoA/ROCK Pathway to Induce Cytoskeleton Remodeling in Nucleus Pulposus Cells
por: Li, Zheng, et al.
Publicado: (2014)

MicroRNA-10b Promotes Nucleus Pulposus Cell Proliferation through RhoC-Akt Pathway by Targeting HOXD10 in Intervetebral Disc Degeneration
por: Yu, Xin, et al.
Publicado: (2013)

Resveratrol protects human nucleus pulposus cells from degeneration by blocking IL-6/JAK/STAT3 pathway
por: Wu, Cenhao, et al.
Publicado: (2021)

A Novel Antithrombocytopenia Agent, Rhizoma cibotii, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways
por: Chen, Wang, et al.
Publicado: (2022)

Merkel cell polyomavirus–negative Merkel cell carcinoma is associated with JAK‐STAT and MEK‐ERK pathway activation
por: Iwasaki, Takeshi, et al.
Publicado: (2021)

Vitamin A Deficiency Induces Congenital Spinal Deformities in Rats
por: Li, Zheng, et al.
Publicado: (2012)

Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells
por: Xiao, Quan, et al.
Publicado: (2021)

Leptin-Induced JAK/STAT Signaling and Cancer Growth
por: Mullen, McKay, et al.
Publicado: (2016)

Leptin Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells through the Cooperative Action of MAPK/ERK1/2, JAK2/STAT3 and PI3K/AKT Signaling Pathways
por: Tan, Ruolan, et al.
Publicado: (2023)

HBx Protein Promotes Oval Cell Proliferation by Up-Regulation of Cyclin D1 via Activation of the MEK/ERK and PI3K/Akt Pathways
por: Wang, Heng-Yi, et al.
Publicado: (2014)

Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo
por: Bai, Xiaoliang, et al.
Publicado: (2022)

Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways
por: Derghal, Adel, et al.
Publicado: (2019)

Expression of EGFR and Molecules Downstream to PI3K/Akt, Raf-1-MEK-1-MAP (Erk1/2), and JAK (STAT3) Pathways in Invasive Lung Adenocarcinomas Resected at a Single Institution
por: Torres, Alba Fabiola, et al.
Publicado: (2014)

Retraction: Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells
Publicado: (2023)

MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1β through the MEK-Erk1/2 and Jak/Stat3 Pathways
por: Zhang, Zeng-Qiao, et al.
Publicado: (2021)

Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells
por: Du, Wei, et al.
Publicado: (2021)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK
por: El-Zein, Ola, et al.
Publicado: (2013)

Calcium Phosphate Cement Causes Nucleus Pulposus Cell Degeneration through the ERK Signaling Pathway
por: Zhou, Quan, et al.
Publicado: (2020)

Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway
por: Ramakrishnan, Vijay, et al.
Publicado: (2012)

Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance
por: Shi, Lei, et al.
Publicado: (2010)

Tanshinone IIA and Astragaloside IV Inhibit miR-223/JAK2/STAT1 Signalling Pathway to Alleviate Lipopolysaccharide-Induced Damage in Nucleus Pulposus Cells
por: Du, Xiaoxun, et al.
Publicado: (2021)

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
por: Li, Qingfang, et al.
Publicado: (2022)

Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway
por: Ye, Dongping, et al.
Publicado: (2018)

miR-155 Inhibits Nucleus Pulposus Cells' Degeneration through Targeting ERK 1/2
por: Ye, Dongping, et al.
Publicado: (2016)

USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway
por: Yu, Bin, et al.
Publicado: (2020)

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons
por: Modi, Prashant Kumar, et al.
Publicado: (2012)

Growth Inhibitory Signaling of the Raf/MEK/ERK Pathway
por: Wu, Pui-Kei, et al.
Publicado: (2020)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

TNFα Mediated IL-6 Secretion Is Regulated by JAK/STAT Pathway but Not by MEK Phosphorylation and AKT Phosphorylation in U266 Multiple Myeloma Cells
por: Lee, Chansu, et al.
Publicado: (2013)

JAK/STAT Signaling and Cervical Cancer: From the Cell Surface to the Nucleus
por: Valle-Mendiola, Arturo, et al.
Publicado: (2023)

Corrigendum to “Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway”
por: Ye, Dongping, et al.
Publicado: (2018)

RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy
por: Yajima, Ichiro, et al.
Publicado: (2012)

Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells
por: Wang, Shaojun, et al.
Publicado: (2019)

Ciliary Neurotrophic Factor Derived From Astrocytes Protects Retinal Ganglion Cells Through PI3K/AKT, JAK/STAT, and MAPK/ERK Pathways
por: Lee, Kwanghyun, et al.
Publicado: (2022)

Icariin Prevents IL-1β-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway
por: Deng, Xiangyu, et al.
Publicado: (2017)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t49f5qsk11kg4fnkpntvcube7u