Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments

The thymus imparts a developmental imprint upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities. Cortical thymic epithelial cells (CTEC) present self-peptide self-MHC complexes to thymocytes, positively selecting those with functional TCRs. Importantly, CTEC gener...

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Detalles Bibliográficos
Autores principales: Jenkinson, William E., Nakamura, Kyoko, White, Andrea J., Jenkinson, Eric J., Anderson, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534071/
https://www.ncbi.nlm.nih.gov/pubmed/23300927
http://dx.doi.org/10.1371/journal.pone.0053416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534071/
https://www.ncbi.nlm.nih.gov/pubmed/23300927
http://dx.doi.org/10.1371/journal.pone.0053416

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