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Normal T Cell Selection Occurs in CD205-Deficient Thymic Microenvironments

The thymus imparts a developmental imprint upon T cells, screening beneficial and self-tolerant T cell receptor (TCR) specificities. Cortical thymic epithelial cells (CTEC) present self-peptide self-MHC complexes to thymocytes, positively selecting those with functional TCRs. Importantly, CTEC gener...

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Detalles Bibliográficos
Autores principales:	Jenkinson, William E., Nakamura, Kyoko, White, Andrea J., Jenkinson, Eric J., Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534071/ https://www.ncbi.nlm.nih.gov/pubmed/23300927 http://dx.doi.org/10.1371/journal.pone.0053416

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