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Depletion of Nuclear Poly(A) Binding Protein PABPN1 Produces a Compensatory Response by Cytoplasmic PABP4 and PABP5 in Cultured Human Cells

BACKGROUND: In vertebrates, poly(A) binding protein (PABP) is known to exist in five different isoforms. PABPs are primarily cytosolic with the exception of the nuclear PABP (PABPN1), which is located in the nucleus. Within the nucleus, PABPN1 is believed to bind to the poly(A) tail of nascent mRNA...

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Detalles Bibliográficos
Autores principales: Bhattacharjee, Rumpa Biswas, Bag, Jnanankur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534090/
https://www.ncbi.nlm.nih.gov/pubmed/23300856
http://dx.doi.org/10.1371/journal.pone.0053036

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