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IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?
BACKGROUND: Fibrosis is a serious consequence of Crohn’s disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. METHODS: Factors potentially modulating collagen deposition were examined in i...
Autores principales: | Bailey, Jennifer R., Bland, Paul W., Tarlton, John F., Peters, Iain, Moorghen, Moganaden, Sylvester, Paul A., Probert, Christopher S. J., Whiting, Christine V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534115/ https://www.ncbi.nlm.nih.gov/pubmed/23300643 http://dx.doi.org/10.1371/journal.pone.0052332 |
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