A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells

Pituitary adenomas can express and secrete different hormones. Expression of pituitary hormones in nonneoplastic pituitary cells is regulated by different transcription factors. Some pituitary adenomas show plurihormonal expression. The most commonly reported plurihormonal adenomas are composed of s...

Descripción completa

Detalles Bibliográficos
Autores principales: Kannan, Subramanian, Staugaitis, Susan M., Weil, Robert J., Hatipoglu, Betul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534206/
https://www.ncbi.nlm.nih.gov/pubmed/23320206
http://dx.doi.org/10.1155/2012/529730
_version_ 1782475291460894720
author Kannan, Subramanian
Staugaitis, Susan M.
Weil, Robert J.
Hatipoglu, Betul
author_facet Kannan, Subramanian
Staugaitis, Susan M.
Weil, Robert J.
Hatipoglu, Betul
author_sort Kannan, Subramanian
collection PubMed
description Pituitary adenomas can express and secrete different hormones. Expression of pituitary hormones in nonneoplastic pituitary cells is regulated by different transcription factors. Some pituitary adenomas show plurihormonal expression. The most commonly reported plurihormonal adenomas are composed of somatotrophs, lactotrophs, thyrotrophs and gonadotrophs. Pituitary adenomas composed of both corticotroph and somatolactotroph secreting cells are not common because transcription factors regulating the expression of these hormones are different. We report a rare case of pituitary adenoma with concomitant corticotroph, prolactin, and growth hormone staining cells, review literature on similar cases, and discuss possible biological mechanisms underlying these plurihormonal tumors.
format Online
Article
Text
id pubmed-3534206
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-35342062013-01-14 A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells Kannan, Subramanian Staugaitis, Susan M. Weil, Robert J. Hatipoglu, Betul Case Rep Endocrinol Case Report Pituitary adenomas can express and secrete different hormones. Expression of pituitary hormones in nonneoplastic pituitary cells is regulated by different transcription factors. Some pituitary adenomas show plurihormonal expression. The most commonly reported plurihormonal adenomas are composed of somatotrophs, lactotrophs, thyrotrophs and gonadotrophs. Pituitary adenomas composed of both corticotroph and somatolactotroph secreting cells are not common because transcription factors regulating the expression of these hormones are different. We report a rare case of pituitary adenoma with concomitant corticotroph, prolactin, and growth hormone staining cells, review literature on similar cases, and discuss possible biological mechanisms underlying these plurihormonal tumors. Hindawi Publishing Corporation 2012 2012-12-17 /pmc/articles/PMC3534206/ /pubmed/23320206 http://dx.doi.org/10.1155/2012/529730 Text en Copyright © 2012 Subramanian Kannan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kannan, Subramanian
Staugaitis, Susan M.
Weil, Robert J.
Hatipoglu, Betul
A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title_full A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title_fullStr A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title_full_unstemmed A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title_short A Rare Corticotroph-Secreting Tumor with Coexisting Prolactin and Growth Hormone Staining Cells
title_sort rare corticotroph-secreting tumor with coexisting prolactin and growth hormone staining cells
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534206/
https://www.ncbi.nlm.nih.gov/pubmed/23320206
http://dx.doi.org/10.1155/2012/529730
work_keys_str_mv AT kannansubramanian ararecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT staugaitissusanm ararecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT weilrobertj ararecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT hatipoglubetul ararecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT kannansubramanian rarecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT staugaitissusanm rarecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT weilrobertj rarecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells
AT hatipoglubetul rarecorticotrophsecretingtumorwithcoexistingprolactinandgrowthhormonestainingcells

Ejemplares similares