Morphologic and Functional Effects of Gamma Secretase Inhibition on Splenic Marginal Zone B Cells

The γ-secretase complex is a promising target in Alzheimer's disease because of its role in the amyloidogenic processing of β-amyloid precursor protein. This enzyme also catalyzes the cleavage of Notch receptor, resulting in the nuclear translocation of intracellular Notch where it modulates ge...

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Detalles Bibliográficos
Autores principales: de Vera Mudry, Maria Cristina, Regenass-Lechner, Franziska, Ozmen, Laurence, Altmann, Bernd, Festag, Matthias, Singer, Thomas, Müller, Lutz, Jacobsen, Helmut, Flohr, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534238/
https://www.ncbi.nlm.nih.gov/pubmed/23316412
http://dx.doi.org/10.1155/2012/289412

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