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A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin

This review focuses on the diagnostic value of hybrid F18-FDG Positron Emission Tomography/Computerized tomography (PET/CT) in fever of unknown origin (FUO) and inflammation of unknown origin (IUO). Due to the wide range of possible causes both FUO and IUO remain a clinical challenge for both patien...

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Autores principales: Balink, H., Verberne, H. J., Bennink, R. J., van Eck-Smit, B. L. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534311/
https://www.ncbi.nlm.nih.gov/pubmed/23316356
http://dx.doi.org/10.1155/2012/165080
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author Balink, H.
Verberne, H. J.
Bennink, R. J.
van Eck-Smit, B. L. F.
author_facet Balink, H.
Verberne, H. J.
Bennink, R. J.
van Eck-Smit, B. L. F.
author_sort Balink, H.
collection PubMed
description This review focuses on the diagnostic value of hybrid F18-FDG Positron Emission Tomography/Computerized tomography (PET/CT) in fever of unknown origin (FUO) and inflammation of unknown origin (IUO). Due to the wide range of possible causes both FUO and IUO remain a clinical challenge for both patients and physicians. In addition, the aetiology of IUO shows the same variation in diseases as the FUO spectrum and probably requires the same diagnostic approach as FUO. There are numerous historically used diagnostic approaches incorporating invasive and non-invasive, and imaging techniques, all with relative high specificity but limited sensitivity. This hampers the generalization of these diagnostic approaches. However, recently published reports show that F18-FDG PET/CT in FUO and IUO has a high sensitivity and a relative non-specificity for malignancy, infection and inflammation. This makes F18-FDG PET/CT an ideal diagnostic tool to start the diagnostic process and to guide subsequent focused diagnostic approaches with higher specificity. In addition, F18-FDG PET/CT has a relative high negative predictive value. Therefore F18 FDG PET/CT should be incorporated in the routine diagnostic work-up of patients with FUO and IUO, preferably at an early stage in the diagnostic process.
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spelling pubmed-35343112013-01-11 A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin Balink, H. Verberne, H. J. Bennink, R. J. van Eck-Smit, B. L. F. Int J Mol Imaging Review Article This review focuses on the diagnostic value of hybrid F18-FDG Positron Emission Tomography/Computerized tomography (PET/CT) in fever of unknown origin (FUO) and inflammation of unknown origin (IUO). Due to the wide range of possible causes both FUO and IUO remain a clinical challenge for both patients and physicians. In addition, the aetiology of IUO shows the same variation in diseases as the FUO spectrum and probably requires the same diagnostic approach as FUO. There are numerous historically used diagnostic approaches incorporating invasive and non-invasive, and imaging techniques, all with relative high specificity but limited sensitivity. This hampers the generalization of these diagnostic approaches. However, recently published reports show that F18-FDG PET/CT in FUO and IUO has a high sensitivity and a relative non-specificity for malignancy, infection and inflammation. This makes F18-FDG PET/CT an ideal diagnostic tool to start the diagnostic process and to guide subsequent focused diagnostic approaches with higher specificity. In addition, F18-FDG PET/CT has a relative high negative predictive value. Therefore F18 FDG PET/CT should be incorporated in the routine diagnostic work-up of patients with FUO and IUO, preferably at an early stage in the diagnostic process. Hindawi Publishing Corporation 2012 2012-12-17 /pmc/articles/PMC3534311/ /pubmed/23316356 http://dx.doi.org/10.1155/2012/165080 Text en Copyright © 2012 H. Balink et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Balink, H.
Verberne, H. J.
Bennink, R. J.
van Eck-Smit, B. L. F.
A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title_full A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title_fullStr A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title_full_unstemmed A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title_short A Rationale for the Use of F18-FDG PET/CT in Fever and Inflammation of Unknown Origin
title_sort rationale for the use of f18-fdg pet/ct in fever and inflammation of unknown origin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534311/
https://www.ncbi.nlm.nih.gov/pubmed/23316356
http://dx.doi.org/10.1155/2012/165080
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