Cargando…

An adjuvanted respiratory syncytial virus fusion protein induces protection in aged BALB/c mice

BACKGROUND: Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current efforts, there is no RSV vaccine currently licensed in infants or elderly adult...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cherukuri, Anu, Stokes, Kate L, Patton, Kathryn, Kuo, Howard, Sakamoto, Kaori, Lambert, Stacie, Stillman, Elizabeth, Moore, Martin L, Lee, Sujin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534329/ https://www.ncbi.nlm.nih.gov/pubmed/23031690 http://dx.doi.org/10.1186/1742-4933-9-21

Ejemplares similares

An immunocompromised BALB/c mouse model for respiratory syncytial virus infection
por: Kong, Xiaoyuan, et al.
Publicado: (2005)

EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression
por: Currier, Michael G., et al.
Publicado: (2016)

A Novel Respiratory Syncytial Virus (RSV) F Subunit Vaccine Adjuvanted with GLA-SE Elicits Robust Protective T(H)1-Type Humoral and Cellular Immunity In Rodent Models
por: Lambert, Stacie L., et al.
Publicado: (2015)

Respiratory Syncytial Virus F Subunit Vaccine With AS02 Adjuvant Elicits Balanced, Robust Humoral and Cellular Immunity in BALB/c Mice
por: Zheng, Yu, et al.
Publicado: (2020)

Dose Selection for an Adjuvanted Respiratory Syncytial Virus F Protein Vaccine for Older Adults Based on Humoral and Cellular Immune Responses
por: Falloon, Judith, et al.
Publicado: (2017)

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus
por: Sastry, Mallika, et al.
Publicado: (2017)

Refining the Balance of Attenuation and Immunogenicity of Respiratory Syncytial Virus by Targeted Codon Deoptimization of Virulence Genes
por: Meng, Jia, et al.
Publicado: (2014)

Development of a High-Throughput Respiratory Syncytial Virus Fluorescent Focus-Based Microneutralization Assay
por: Shambaugh, Cindy, et al.
Publicado: (2017)

Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice
por: Bian, Lijun, et al.
Publicado: (2022)

Pathogenesis of Respiratory Syncytial Virus Infection in BALB/c Mice Differs Between Intratracheal and Intranasal Inoculation
por: van Erp, Elisabeth A., et al.
Publicado: (2019)

An Overview of Respiratory Syncytial Virus
por: Meng, Jia, et al.
Publicado: (2014)

The protective immunity induced by intranasally inoculated serotype 63 chimpanzee adenovirus vector expressing human respiratory syncytial virus prefusion fusion glycoprotein in BALB/c mice
por: Huang, Lei, et al.
Publicado: (2022)

Intranasal immunization with a helper-dependent adenoviral vector expressing the codon-optimized fusion glycoprotein of human respiratory syncytial virus elicits protective immunity in BALB/c mice
por: Fu, Yuan-Hui, et al.
Publicado: (2013)

Induction of high titred, non-neutralising antibodies by self-adjuvanting peptide epitopes derived from the respiratory syncytial virus fusion protein
por: Jaberolansar, Noushin, et al.
Publicado: (2017)

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor
por: Roymans, Dirk, et al.
Publicado: (2017)

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein
por: Tian, Daiyin, et al.
Publicado: (2017)

Mechanisms of Respiratory Syncytial Virus Modulation of Airway Immune Responses
por: Lotz, Matthew T., et al.
Publicado: (2012)

Intranasal immunization with a single dose of the fusion protein formulated with a combination adjuvant induces long-term protective immunity against respiratory syncytial virus
por: Garg, R., et al.
Publicado: (2017)

Innate Type 2 Responses to Respiratory Syncytial Virus Infection
por: Norlander, Allison E., et al.
Publicado: (2020)

Exploring Key Genes and Mechanisms in Respiratory Syncytial Virus-Infected BALB/c Mice via Multi-Organ Expression Profiles
por: He, Yu, et al.
Publicado: (2022)

Decrease in Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) Enhanced Disease with RSV G Glycoprotein Peptide Immunization in BALB/c Mice
por: Rey, Gertrud U., et al.
Publicado: (2013)

Combination Therapy Using Monoclonal Antibodies against Respiratory Syncytial Virus (RSV) G Glycoprotein Protects from RSV Disease in BALB/c Mice
por: Caidi, Hayat, et al.
Publicado: (2012)

Respiratory syncytial virus
por: Ruuskanen, Olli, et al.
Publicado: (1993)

Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus
por: Huck, Barbara, et al.
Publicado: (2007)

Virus genes and host correlates of pathology are markedly reduced during respiratory syncytial and influenza virus co-infection in BALB/c mice
por: Ayegbusi, Olaitan T., et al.
Publicado: (2019)

The Optimal Concentration of Formaldehyde is Key to Stabilizing the Pre-Fusion Conformation of Respiratory Syncytial Virus Fusion Protein
por: Zhang, Wei, et al.
Publicado: (2019)

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
por: Mousa, Jarrod J., et al.
Publicado: (2017)

Role of oligosaccharides in the structure and function of respiratory syncytial virus glycoproteins
por: Lambert, Dennis M.
Publicado: (1988)

Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006–2010
por: Papenburg, Jesse, et al.
Publicado: (2012)

Pre-fusion F is absent on the surface of formalin-inactivated respiratory syncytial virus
por: Killikelly, April M., et al.
Publicado: (2016)

Discovery of N-Containing (-)-Borneol Esters as Respiratory Syncytial Virus Fusion Inhibitors
por: Sokolova, Anastasiya S., et al.
Publicado: (2022)

CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns
por: van Haren, Simon D., et al.
Publicado: (2022)

Dual Role of Respiratory Syncytial Virus Glycoprotein Fragment as a Mucosal Immunogen and Chemotactic Adjuvant
por: Kim, Sol, et al.
Publicado: (2012)

Assessing the Adjuvant Effect of Layered Double Hydroxides (LDH) on BALB/c Mice
por: Govea-Alonso, Dania O., et al.
Publicado: (2023)

Detailed Molecular Interactions between Respiratory Syncytial Virus Fusion Protein and the TLR4/MD-2 Complex In Silico
por: Akagawa, Mao, et al.
Publicado: (2022)

IL-13 is associated with reduced illness and replication in primary respiratory syncytial virus infection in the mouse
por: Zhou, Weisong, et al.
Publicado: (2006)

Molecular Epidemiology and Phylodynamics of the Human Respiratory Syncytial Virus Fusion Protein in Northern Taiwan
por: Chi, Hsin, et al.
Publicado: (2013)

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus
por: Boyington, Jeffrey C., et al.
Publicado: (2016)

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine
por: Joyce, M. Gordon, et al.
Publicado: (2016)

Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein
por: Flynn, Jessica A., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_e65nrcpdqt21q5sc8co83tgjmv