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Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus

BACKGROUND: The aim of this study is to compare clinical outcomes between patients with solitary lymph node metastasis and node-negative (N0) patients in squamous cell carcinoma of the middle thoracic esophagus. METHODS: A series of 135 patients with squamous cell carcinoma of the middle thoracic es...

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Autores principales: Wu, Jie, Chen, Qi-Xun, Zhou, Xing-Ming, Mao, Wei-Ming, Krasna, Mark J, Teng, Li-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534583/
https://www.ncbi.nlm.nih.gov/pubmed/23036154
http://dx.doi.org/10.1186/1477-7819-10-210
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author Wu, Jie
Chen, Qi-Xun
Zhou, Xing-Ming
Mao, Wei-Ming
Krasna, Mark J
Teng, Li-Song
author_facet Wu, Jie
Chen, Qi-Xun
Zhou, Xing-Ming
Mao, Wei-Ming
Krasna, Mark J
Teng, Li-Song
author_sort Wu, Jie
collection PubMed
description BACKGROUND: The aim of this study is to compare clinical outcomes between patients with solitary lymph node metastasis and node-negative (N0) patients in squamous cell carcinoma of the middle thoracic esophagus. METHODS: A series of 135 patients with squamous cell carcinoma of the middle thoracic esophagus were retrospectively investigated. There were 33 patients with solitary lymph node metastasis and 102 N0 patients. Skip metastasis in 33 patients with solitary lymph node metastasis was defined according to three criteria: Japanese Society for Esophageal Disease (JSED), American Joint Commission on Cancer (AJCC), and the anatomical compartment. RESULTS: In 33 patients with solitary lymph node metastasis, skip metastasis was shown in 13, 23, and 8 patients according JSED, AJCC and anatomical compartment respectively. The 5-year survival rates for N0 patients and patients with solitary lymph node metastasis were 58% and 32% respectively (P =0.008). Multivariate analysis revealed that skip metastasis was not an independent prognostic factor. CONCLUSIONS: For patients with middle thoracic esophageal squamous cell carcinoma, solitary lymph node metastasis has a negative impact on survival compared with N0 disease; skip metastasis, however, is comparable to N0 diseases in predicting prognosis.
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spelling pubmed-35345832013-01-03 Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus Wu, Jie Chen, Qi-Xun Zhou, Xing-Ming Mao, Wei-Ming Krasna, Mark J Teng, Li-Song World J Surg Oncol Research BACKGROUND: The aim of this study is to compare clinical outcomes between patients with solitary lymph node metastasis and node-negative (N0) patients in squamous cell carcinoma of the middle thoracic esophagus. METHODS: A series of 135 patients with squamous cell carcinoma of the middle thoracic esophagus were retrospectively investigated. There were 33 patients with solitary lymph node metastasis and 102 N0 patients. Skip metastasis in 33 patients with solitary lymph node metastasis was defined according to three criteria: Japanese Society for Esophageal Disease (JSED), American Joint Commission on Cancer (AJCC), and the anatomical compartment. RESULTS: In 33 patients with solitary lymph node metastasis, skip metastasis was shown in 13, 23, and 8 patients according JSED, AJCC and anatomical compartment respectively. The 5-year survival rates for N0 patients and patients with solitary lymph node metastasis were 58% and 32% respectively (P =0.008). Multivariate analysis revealed that skip metastasis was not an independent prognostic factor. CONCLUSIONS: For patients with middle thoracic esophageal squamous cell carcinoma, solitary lymph node metastasis has a negative impact on survival compared with N0 disease; skip metastasis, however, is comparable to N0 diseases in predicting prognosis. BioMed Central 2012-10-04 /pmc/articles/PMC3534583/ /pubmed/23036154 http://dx.doi.org/10.1186/1477-7819-10-210 Text en Copyright ©2012 Wu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wu, Jie
Chen, Qi-Xun
Zhou, Xing-Ming
Mao, Wei-Ming
Krasna, Mark J
Teng, Li-Song
Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title_full Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title_fullStr Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title_full_unstemmed Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title_short Prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
title_sort prognostic significance of solitary lymph node metastasis in patients with squamous cell carcinoma of middle thoracic esophagus
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534583/
https://www.ncbi.nlm.nih.gov/pubmed/23036154
http://dx.doi.org/10.1186/1477-7819-10-210
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