LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

BACKGROUND: Long interspersed nucleotide element 1 (LINE-1) hypomethylation is suggested to play a role in the progression of colorectal cancer (CRC). To assess intra-patient heterogeneity of LINE-1 methylation in CRC and to understand its biological relevance in invasion and metastasis, we evaluate...

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Detalles Bibliográficos
Autores principales: Matsunoki, Aika, Kawakami, Kazuyuki, Kotake, Masanori, Kaneko, Mami, Kitamura, Hirotaka, Ooi, Akishi, Watanabe, Go, Minamoto, Toshinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534591/
https://www.ncbi.nlm.nih.gov/pubmed/23216958
http://dx.doi.org/10.1186/1471-2407-12-574

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