Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles

BACKGROUND: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation. RESULTS: Microwave-induced polystyren...

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Detalles Bibliográficos
Autores principales: Cárdenas, Rosario Astrid Vargas, Leal, Blanca Olinda Quintanilla, Reddy, Ashwini, Bandyopadhyay, Debasish, Banik, Bimal K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534635/
https://www.ncbi.nlm.nih.gov/pubmed/22726766
http://dx.doi.org/10.1186/2191-2858-2-24
Descripción
Sumario:BACKGROUND: Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation. RESULTS: Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrofuran has been accomplished with excellent yield. This method produces pyrroles with polyaromatic amines. CONCLUSION: The present procedure for the synthesis of N-aromatic substituted pyrroles will find useful application in the area of pharmacologically active molecules.

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