Cargando…

AMPK Activators Suppress Cervical Cancer Cell Growth through Inhibition of DVL3 Mediated Wnt/β-Catenin Signaling Activity

Recent evidence has suggested that AMPK activators may be applied as therapeutic drugs in suppressing cancer cell growth. However, the molecular mechanism of their suppressive function in cancer cells is still unclear. Here we show that AMPK activators impair cervical cancer cell growth through the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwan, H. T., Chan, David W., Cai, Patty C. H., Mak, Celia S. L., Yung, Mingo M. H., Leung, Thomas H. Y., Wong, Oscar G. W., Cheung, Annie N. Y., Ngan, Hextan Y. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534705/ https://www.ncbi.nlm.nih.gov/pubmed/23301094 http://dx.doi.org/10.1371/journal.pone.0053597

Ejemplares similares

Down-regulation of Sox7 is associated with aberrant activation of Wnt/β-catenin signaling in endometrial cancer
por: Chan, David W, et al.
Publicado: (2012)

Orchestrated Action of AMPK Activation and Combined VEGF/PD-1 Blockade with Lipid Metabolic Tunning as Multi-Target Therapeutics against Ovarian Cancers
por: Yung, Mingo M. H., et al.
Publicado: (2022)

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade
por: Yung, Mingo M. H., et al.
Publicado: (2015)

Targeting GRB7/ERK/FOXM1 Signaling Pathway Impairs Aggressiveness of Ovarian Cancer Cells
por: Chan, David W., et al.
Publicado: (2012)

Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung
por: Zhu, Yuting, et al.
Publicado: (2023)

Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/β-catenin signaling activation
por: Liu, Yiting, et al.
Publicado: (2023)

Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
por: Yung, Mingo Ming Ho, et al.
Publicado: (2013)

The Impact of the Tumor Microenvironment on Macrophage Polarization in Cancer Metastatic Progression
por: Wang, Huogang, et al.
Publicado: (2021)

FUBP1 promotes colorectal cancer stemness and metastasis via DVL1‐mediated activation of Wnt/β‐catenin signaling
por: Yin, Haofan, et al.
Publicado: (2021)

Neuroglobin Regulates Wnt/β-Catenin and NFκB Signaling Pathway through Dvl1
por: Xun, Yu, et al.
Publicado: (2018)

MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
por: Mak, Celia S. L., et al.
Publicado: (2017)

ASPM promotes hepatocellular carcinoma progression by activating Wnt/β‐catenin signaling through antagonizing autophagy‐mediated Dvl2 degradation
por: Zhang, Haifeng, et al.
Publicado: (2021)

Increased Expression of PITX2 Transcription Factor Contributes to Ovarian Cancer Progression
por: Fung, Frederic K. C., et al.
Publicado: (2012)

Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
por: Mo, Yulan, et al.
Publicado: (2023)

New Insights into Ferroptosis Initiating Therapies (FIT) by Targeting the Rewired Lipid Metabolism in Ovarian Cancer Peritoneal Metastases
por: Zhan, Shijie, et al.
Publicado: (2022)

The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment
por: Liang, Rui, et al.
Publicado: (2021)

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells
por: Lok, Gabriel T. M., et al.
Publicado: (2011)

Mutations in the Human naked cuticle Homolog NKD1 Found in Colorectal Cancer Alter Wnt/Dvl/β-Catenin Signaling
por: Guo, Jianhui, et al.
Publicado: (2009)

RNA-Binding Protein MEX3A Interacting with DVL3 Stabilizes Wnt/β-Catenin Signaling in Endometrial Carcinoma
por: Yang, Pusheng, et al.
Publicado: (2022)

Suppression of Wnt/β-catenin Signaling in PDAC via METTL16-mediated N6-methyladenosine Modification of DVL2
por: Yu, Lanting, et al.
Publicado: (2023)

The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism
por: Mentink, Remco A., et al.
Publicado: (2018)

Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma
por: Sremac, Maja, et al.
Publicado: (2021)

SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance
por: Li, Jing, et al.
Publicado: (2021)

Metabolic active peritoneal sites affect tumor debulking in ovarian and peritoneal cancers
por: Tsoi, Tung Tung, et al.
Publicado: (2020)

Brain Metastases from Lung Cancer Show Increased Expression of DVL1, DVL3 and Beta-Catenin and Down-Regulation of E-Cadherin
por: Kafka, Anja, et al.
Publicado: (2014)

ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size
por: Kadir, Rotem, et al.
Publicado: (2016)

Elevated TAK1 augments tumor growth and metastatic capacities of ovarian cancer cells through activation of NF-κB signaling
por: Cai, Patty C.H., et al.
Publicado: (2014)

CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling
por: Zhu, Lili, et al.
Publicado: (2022)

The small molecule indirubin-3′-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity
por: Choi, O M, et al.
Publicado: (2014)

SPARCL1 suppresses osteosarcoma metastasis and recruits macrophages by activation of canonical WNT/β-catenin signaling through stabilization of the WNT–receptor complex
por: Zhao, S-J, et al.
Publicado: (2018)

PFKFB3 Regulates Chemoresistance, Metastasis and Stemness via IAP Proteins and the NF-κB Signaling Pathway in Ovarian Cancer
por: Jiang, Yu-xin, et al.
Publicado: (2022)

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification
por: Nielsen, Casey P., et al.
Publicado: (2019)

Methionine improves feather follicle development in chick embryos by activating Wnt/β-catenin signaling
por: Chen, M.J., et al.
Publicado: (2020)

Different behaviour of DVL1, DVL2, DVL3 in astrocytoma malignancy grades and their association to TCF1 and LEF1 upregulation
por: Kafka, Anja, et al.
Publicado: (2018)

p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation
por: Siu, Michelle K. Y., et al.
Publicado: (2015)

Aralia armata (Wall.) Seem Improves Intimal Hyperplasia after Vascular Injury by Downregulating the Wnt3α/Dvl-1/β-Catenin Pathway
por: Zhao, Xiangpei, et al.
Publicado: (2021)

HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34(+) hematopoietic progenitor cells
por: Dirck, Aaron, et al.
Publicado: (2023)

Superresolution microscopy localizes endogenous Dvl2 to Wnt signaling-responsive biomolecular condensates
por: Schubert, Antonia, et al.
Publicado: (2022)

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy
por: Wong, D W L, et al.
Publicado: (2016)

Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice
por: He, Wei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4e8lvr98ecm9qu1gahq9usiu8i