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Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

The blood–brain barrier and blood–spinal cord barrier (BSCB) limit the entry of plasma components and erythrocytes into the central nervous system (CNS). Pericytes play a key role in maintaining blood–CNS barriers. The BSCB is damaged in patients with amyotrophic lateral sclerosis (ALS). Moreover, t...

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Detalles Bibliográficos
Autores principales: Winkler, Ethan A., Sengillo, Jesse D., Sullivan, John S., Henkel, Jenny S., Appel, Stanley H., Zlokovic, Berislav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535352/
https://www.ncbi.nlm.nih.gov/pubmed/22941226
http://dx.doi.org/10.1007/s00401-012-1039-8