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The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10

The in vivo roles of meprin metalloproteases in pathophysiological conditions remain elusive. Substrates define protease roles. Therefore, to identify natural substrates for human meprin α and β we employed TAILS (terminal amine isotopic labeling of substrates), a proteomics approach that enriches f...

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Detalles Bibliográficos
Autores principales:	Jefferson, Tamara, auf dem Keller, Ulrich, Bellac, Caroline, Metz, Verena V., Broder, Claudia, Hedrich, Jana, Ohler, Anke, Maier, Wladislaw, Magdolen, Viktor, Sterchi, Erwin, Bond, Judith S., Jayakumar, Arumugam, Traupe, Heiko, Chalaris, Athena, Rose-John, Stefan, Pietrzik, Claus U., Postina, Rolf, Overall, Christopher M., Becker-Pauly, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SP Birkhäuser Verlag Basel 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535375/ https://www.ncbi.nlm.nih.gov/pubmed/22940918 http://dx.doi.org/10.1007/s00018-012-1106-2

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