The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections

HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of the repeat-in-toxin (RtxA1) gene, one of the most important vi...

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Autores principales: Liu, Moqing, Crosa, Jorge H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535394/
https://www.ncbi.nlm.nih.gov/pubmed/23233275
http://dx.doi.org/10.1002/mbo3.48
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author Liu, Moqing
Crosa, Jorge H
author_facet Liu, Moqing
Crosa, Jorge H
author_sort Liu, Moqing
collection PubMed
description HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of the repeat-in-toxin (RtxA1) gene, one of the most important virulence factors accounting for the fulminating and damaging nature of V. vulnificus infections. In this work, we reviewed the latest studies of RtxA1 in this bacterium and highlight the mechanism of gene regulation of rtxA1 expression by HlyU under a broader gene regulatory network.
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spelling pubmed-35353942013-01-08 The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections Liu, Moqing Crosa, Jorge H Microbiologyopen Review HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of the repeat-in-toxin (RtxA1) gene, one of the most important virulence factors accounting for the fulminating and damaging nature of V. vulnificus infections. In this work, we reviewed the latest studies of RtxA1 in this bacterium and highlight the mechanism of gene regulation of rtxA1 expression by HlyU under a broader gene regulatory network. Blackwell Publishing Ltd 2012-12 2012-11-28 /pmc/articles/PMC3535394/ /pubmed/23233275 http://dx.doi.org/10.1002/mbo3.48 Text en © 2012 Published by Blackwell Publishing Ltd. http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Review
Liu, Moqing
Crosa, Jorge H
The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title_full The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title_fullStr The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title_full_unstemmed The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title_short The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections
title_sort regulator hlyu, the repeat-in-toxin gene rtxa1, and their roles in the pathogenesis of vibrio vulnificus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535394/
https://www.ncbi.nlm.nih.gov/pubmed/23233275
http://dx.doi.org/10.1002/mbo3.48
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