Cargando…

Analysis of high-throughput RNAi screening data in identifying genes mediating sensitivity to chemotherapeutic drugs: statistical approaches and perspectives

BACKGROUND: High-throughput RNA interference (RNAi) screens have been used to find genes that, when silenced, result in sensitivity to certain chemotherapy drugs. Researchers therefore can further identify drug-sensitive targets and novel drug combinations that sensitize cancer cells to chemotherape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ye, Fei, Bauer, Joshua A, Pietenpol, Jennifer A, Shyr, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535706/ https://www.ncbi.nlm.nih.gov/pubmed/23281588 http://dx.doi.org/10.1186/1471-2164-13-S8-S3

Ejemplares similares

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells
por: Bauer, Joshua A, et al.
Publicado: (2010)

Cell-based high-throughput screens for the discovery of chemotherapeutic agents
por: Fox, Jennifer T., et al.
Publicado: (2012)

Generation of RNAi Libraries for High-Throughput Screens
por: Clark, Julie, et al.
Publicado: (2006)

High-throughput reverse genetics: RNAi screens in Caenorhabditis elegans
por: Bargmann, Cornelia I
Publicado: (2001)

A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron protein
por: McCormack, Nikki M., et al.
Publicado: (2021)

Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
por: Azorsa, David O, et al.
Publicado: (2009)

High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer
por: Williams, Steven P., et al.
Publicado: (2017)

Statistical models for identifying frequent hitters in high throughput screening
por: Goodwin, Samuel, et al.
Publicado: (2020)

Comparative Study of Exome Copy Number Variation Estimation Tools Using Array Comparative Genomic Hybridization as Control
por: Guo, Yan, et al.
Publicado: (2013)

Corrigendum to “Comparative Study of Exome Copy Number Variation Estimation Tools Using Array Comparative Genomic Hybridization as Control”
por: Guo, Yan, et al.
Publicado: (2017)

Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens
por: Yin, Zheng, et al.
Publicado: (2008)

Corrigendum: High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer
por: Williams, Steven P., et al.
Publicado: (2018)

Practicality of identifying mitochondria variants from exome and RNAseq data
por: Zhang, Pan, et al.
Publicado: (2015)

High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons
por: Nieland, Thomas J. F., et al.
Publicado: (2014)

High-throughput RNAi screening of human kinases identifies predictors of clinical outcome in colorectal cancer patients treated with oxaliplatin
por: Lin, Moubin, et al.
Publicado: (2015)

A Novel Multiplex Cell Viability Assay for High-Throughput RNAi Screening
por: Gilbert, Daniel F., et al.
Publicado: (2011)

Quantitative and Automated High-throughput Genome-wide RNAi Screens in C. elegans
por: Squiban, Barbara, et al.
Publicado: (2012)

TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer
por: Chen, Xi, et al.
Publicado: (2012)

Automated High-Throughput RNAi Screening in Human Cells Combined with Reporter mRNA Transfection to Identify Novel Regulators of Translation
por: Casanova, Claudia M., et al.
Publicado: (2012)

Functional fingerprinting of human mesenchymal stem cells using high-throughput RNAi screening
por: Erdmann, Gerrit, et al.
Publicado: (2015)

Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
por: Rohn, Jennifer L., et al.
Publicado: (2011)

RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line
por: Wood, Megan P., et al.
Publicado: (2016)

RNAi screens in mice identify physiological regulators of oncogenic growth
por: Beronja, Slobodan, et al.
Publicado: (2013)

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments
por: Mohni, Kareem N., et al.
Publicado: (2015)

RNAseq by Total RNA Library Identifies Additional RNAs Compared to Poly(A) RNA Library
por: Guo, Yan, et al.
Publicado: (2015)

FlyRNAi: the Drosophila RNAi screening center database
por: Flockhart, Ian, et al.
Publicado: (2006)

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets
por: Kanojia, Deepika, et al.
Publicado: (2017)

A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling
por: Caldarelli, A, et al.
Publicado: (2013)

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
por: Lehtinen, Laura, et al.
Publicado: (2012)

RNAi Screening of Drosophila (Sophophora) melanogaster S2 Cells for Ricin Sensitivity and Resistance
por: Pawar, Vidya, et al.
Publicado: (2011)

A Novel RNAi Lethality Rescue Screen to Identify Regulators of Adipogenesis
por: van Beekum, Olivier, et al.
Publicado: (2012)

A C. elegans genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle function
por: Chaya, Timothy, et al.
Publicado: (2021)

Multidrug resistance genes screening of pancreatic ductal adenocarcinoma based on sensitivity profile to chemotherapeutic drugs
por: Zhao, Bangbo, et al.
Publicado: (2022)

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening
por: Hackman, G. Lavender, et al.
Publicado: (2020)

FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2017 update
por: Hu, Yanhui, et al.
Publicado: (2017)

FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update
por: Hu, Yanhui, et al.
Publicado: (2020)

Canonical Wnt signaling: high-throughput RNAi widens the path
por: Brown, Anthony MC
Publicado: (2005)

Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets
por: Eggert, Ulrike S, et al.
Publicado: (2004)

RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation
por: Doumanis, Joanna, et al.
Publicado: (2009)

Genome-Wide RNAi Screening Identifies Genes Inhibiting the Migration of Glioblastoma Cells
por: Yang, Jian, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_eoekcki5bv2skge9agf1tn6a6j