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Investigating the relationship of DNA methylation with mutation rate and allele frequency in the human genome
BACKGROUND: DNA methylation, which mainly occurs at CpG dinucleotides, is a dynamic epigenetic regulation mechanism in most eukaryotic genomes. It is already known that methylated CpG dinucleotides can lead to a high rate of C to T mutation at these sites. However, less is known about whether and ho...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535710/ https://www.ncbi.nlm.nih.gov/pubmed/23281708 http://dx.doi.org/10.1186/1471-2164-13-S8-S7 |